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dc.contributor.author
Lopez, Nicolas Alfredo
dc.contributor.author
Luengo, Carina Vanesa
dc.contributor.author
Avena, Marcelo Javier
dc.date.available
2022-05-20T10:38:42Z
dc.date.issued
2021-10-12
dc.identifier.citation
Lopez, Nicolas Alfredo; Luengo, Carina Vanesa; Avena, Marcelo Javier; Ciprofloxacin in Layered Double Hydroxides: Looking for the Best Synthesis Method; Elsevier; Journal of Pharmaceutical Sciences; 111; 5; 12-10-2021; 1429-1436
dc.identifier.issn
0022-3549
dc.identifier.uri
http://hdl.handle.net/11336/157896
dc.description.abstract
It is important to develop new methods of release to improve pharmacokinetic parameters of drugs, especially antibiotics, whose plasmatic concentration is determinant to ensure an effective treatment. Layered double hydroxides (LDH) are inorganic and biocompatible materials with high drug intercalation capacity and release properties that can be tuned by controlling the pH value. These materials can be an excellent choice to achieve a sustained release and an optimal drug concentration in plasm. In this work, LDH were synthesized with intercalated ciprofloxacin (CIP) by three different methods: coprecipitation, reconstruction and ion exchange. LDH-CIP complexes were characterized by XRD, TG-DSC, TEM, SEM, FTIR, electrophoretic mobilities, and drug release and dissolution kinetics in NaCl solutions and under physiological conditions. The coprecipitation and reconstruction methods lead to the formation of ill-defined products, whereas the ion exchange method rendered the best intercalation results. CIP release was controlled by dissolution at pH<3 and by desorption and ion exchange at intermediate and high pH. In comparison with a commercial formulation, the LDH-CIP complex prepared by ion exchange presented a slower release profile. The fast dissolution at gastric pH raises the need of developing some type of coating for protecting LDH materials.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
NANOCOMPOSITE
dc.subject
DISSOLUTION
dc.subject
KINETICS
dc.subject
CONTROLLED RELEASE
dc.subject.classification
Otras Ciencias Químicas
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Ciencias Químicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
Ciprofloxacin in Layered Double Hydroxides: Looking for the Best Synthesis Method
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2022-05-17T12:51:21Z
dc.journal.volume
111
dc.journal.number
5
dc.journal.pagination
1429-1436
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Hoboken
dc.description.fil
Fil: Lopez, Nicolas Alfredo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina
dc.description.fil
Fil: Luengo, Carina Vanesa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina
dc.description.fil
Fil: Avena, Marcelo Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina
dc.journal.title
Journal of Pharmaceutical Sciences
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1016/j.xphs.2021.10.014
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0022354921005554
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