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dc.contributor.author
Seremeta, Katia Pamela
dc.contributor.author
Reyes Tur, María I.
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Martínez Pérez, Sandra
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Höcht, Christian
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Taira, Carlos Alberto
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López Hernández, Orestes D.
dc.contributor.author
Sosnik, Alejandro Dario
dc.date.available
2017-04-26T21:17:15Z
dc.date.issued
2014-11
dc.identifier.citation
Seremeta, Katia Pamela; Reyes Tur, María I.; Martínez Pérez, Sandra; Höcht, Christian; Taira, Carlos Alberto; et al.; Spray-dried didanosine-loaded polymeric particles for enhanced oral bioavailability; Elsevier Science; Colloids and Surfaces B: Biointerfaces; 123; 11-2014; 515-523
dc.identifier.issn
0927-7765
dc.identifier.uri
http://hdl.handle.net/11336/15783
dc.description.abstract
Didanosine (ddI) is a water-soluble antiretroviral used in the treatment of HIV that undergoes fast gastric degradation to an inactive hypoxanthine. Therefore, its oral bioavailability is relatively low (20–40%). In this work, we investigated for the first time a scalable open-loop spray-drying method with co-current flow for the encapsulation of ddI (model drug) within particles of the biocompatible polyester poly(epsilon-caprolactone). The average diameter of the particles was 36–118 μm and the morphology spherical. The encapsulation efficiency ranged from 60% to 100% with yields of up to 65%. ATR/FT-IR analysis indicated that most of the drug was encapsulated within the particles. In vitro release assays showed that the particles released the drug within 120 min. Finally, oral administration to rats led to a statistically significant 2.5-fold increase of the bioavailability with respect to a ddI aqueous solution, highlighting the potential of this technology to encapsulate efficiently other hydrophilic antiretrovirals and, by doing so, to overcome different biopharmaceutical drawbacks associated with the oral administration.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Science
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
Hiv Therapy
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Didanosine
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Poly (Epsilon-Caprolactone) Microparticles
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Spray-Drying
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Enhanced Oral Bioavailability
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Otras Ciencias de la Salud
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Ciencias de la Salud
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Spray-dried didanosine-loaded polymeric particles for enhanced oral bioavailability
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-04-26T14:14:15Z
dc.journal.volume
123
dc.journal.pagination
515-523
dc.journal.pais
Países Bajos
dc.journal.ciudad
Ámsterdam
dc.description.fil
Fil: Seremeta, Katia Pamela. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
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Fil: Reyes Tur, María I.. AICA Laboratories; Cuba
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Fil: Martínez Pérez, Sandra. LIORAD Laboratories; Cuba
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Fil: Höcht, Christian. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Farmacología; Argentina
dc.description.fil
Fil: Taira, Carlos Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Farmacología; Argentina
dc.description.fil
Fil: López Hernández, Orestes D.. Ambato Technical University. Faculty of Food Science and Engineering; Ecuador
dc.description.fil
Fil: Sosnik, Alejandro Dario. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Technion - Israel Institute of Technology; Israel
dc.journal.title
Colloids and Surfaces B: Biointerfaces
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.colsurfb.2014.09.055
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0927776514005268
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