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dc.contributor.author
Monti Hughes, Andrea
dc.contributor.author
Heber, Elisa Mercedes
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Pozzi, Emiliano César Cayetano
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Nigg, D. W.
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Calzetta, O.
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Blaumann, Herman Roberto
dc.contributor.author
Longhino, Juan Manuel
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Nievas, Silvia Irene
dc.contributor.author
Aromando, Romina Flavia
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Itoiz, María Elina
dc.contributor.author
Trivillin, Verónica Andrea
dc.contributor.author
Schwint, Amanda Elena
dc.date.available
2022-05-19T18:50:54Z
dc.date.issued
2009-07
dc.identifier.citation
Monti Hughes, Andrea; Heber, Elisa Mercedes; Pozzi, Emiliano César Cayetano; Nigg, D. W.; Calzetta, O.; et al.; Boron neutron capture therapy (BNCT) inhibits tumor development from precancerous tissue: An experimental study that supports a potential new application of BNCT; Pergamon-Elsevier Science Ltd; Applied Radiation and Isotopes; 67; 7-8; 7-2009; 313-317
dc.identifier.issn
0969-8043
dc.identifier.uri
http://hdl.handle.net/11336/157837
dc.description.abstract
We previously demonstrated the efficacy of boron neutron capture therapy (BNCT) mediated by boronophenylalanine (BPA), GB-10 (Na2 10B10H10) and (GB-10+BPA) to control tumors, with no normal tissue radiotoxicity, in the hamster cheek pouch oral cancer model. Herein we developed a novel experimental model of field-cancerization and precancerous lesions (globally termed herein precancerous tissue) in the hamster cheek pouch to explore the long-term potential inhibitory effect of the same BNCT protocols on the development of second primary tumors from precancerous tissue. Clinically, second primary tumor recurrences occur in field-cancerized tissue, causing therapeutic failure. Weperformed boronbiodistribution studies followed by in vivo BNCTstudies, with 8 months followup. All 3 BNCT protocols induced a statistically significant reduction in tumor development from precancerous tissue, reaching a maximum inhibition of 77–100%. The inhibitory effect of BPA-BNCTand (GB-10+BPA)-BNCT persisted at 51% at the end of follow-up (8 months), whereas for GB-10-BNCT it faded after 2 months. Likewise, beam-only elicited a significant but transient reduction in tumor development. No normal tissue radiotoxicity was observed. At 8 months post-treatment with BPA-BNCT or (GB-10+BPA)-BNCT, the precancerous pouches that did not develop tumors had regained the macroscopic and histological appearance of normal (non-cancerized) pouches. A potential new clinical application of BNCT would lie in its capacity to inhibit local regional recurrences.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Pergamon-Elsevier Science Ltd
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
BNCT
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ORAL CANCER
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PRECANCEROUS TISSUE
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HAMSTER CHEEK POUCH
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LOCOREGIONAL RECURRENCES
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Otras Medicina Básica
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Boron neutron capture therapy (BNCT) inhibits tumor development from precancerous tissue: An experimental study that supports a potential new application of BNCT
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2022-05-12T06:33:03Z
dc.journal.volume
67
dc.journal.number
7-8
dc.journal.pagination
313-317
dc.journal.pais
Países Bajos
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Monti Hughes, Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Comisión Nacional de Energía Atómica. Gerencia de Área de Aplicaciones de la Tecnología Nuclear. Departamento de Radiobiología; Argentina
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Fil: Heber, Elisa Mercedes. Comisión Nacional de Energía Atómica. Gerencia de Área de Aplicaciones de la Tecnología Nuclear. Departamento de Radiobiología; Argentina
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Fil: Pozzi, Emiliano César Cayetano. Comisión Nacional de Energía Atómica; Argentina
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Fil: Nigg, D. W.. Idaho National Laboratory; Estados Unidos
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Fil: Calzetta, O.. Comision Nacional de Energia Atomica. Centro Atomico Bariloche. Departamento de Ingeniería Nuclear; Argentina
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Fil: Blaumann, Herman Roberto. Comision Nacional de Energia Atomica. Centro Atomico Bariloche. Departamento de Ingeniería Nuclear; Argentina
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Fil: Longhino, Juan Manuel. Comision Nacional de Energia Atomica. Centro Atomico Bariloche. Departamento de Ingeniería Nuclear; Argentina
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Fil: Nievas, Silvia Irene. Comisión Nacional de Energía Atómica; Argentina
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Fil: Aromando, Romina Flavia. Universidad de Buenos Aires. Facultad de Odontología; Argentina
dc.description.fil
Fil: Itoiz, María Elina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Comisión Nacional de Energía Atómica. Gerencia de Área de Aplicaciones de la Tecnología Nuclear. Departamento de Radiobiología; Argentina. Universidad de Buenos Aires. Facultad de Odontología; Argentina
dc.description.fil
Fil: Trivillin, Verónica Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Comisión Nacional de Energía Atómica. Gerencia de Área de Aplicaciones de la Tecnología Nuclear. Departamento de Radiobiología; Argentina
dc.description.fil
Fil: Schwint, Amanda Elena. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Comisión Nacional de Energía Atómica. Gerencia de Área de Aplicaciones de la Tecnología Nuclear. Departamento de Radiobiología; Argentina
dc.journal.title
Applied Radiation and Isotopes
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.apradiso.2009.03.070
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0969804309003133
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