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Artículo

Circulating cytokine and chemokine profiles of Trypanosoma cruzi-infected women during pregnancy and its association with congenital transmission

Volta, Bibiana; Bustos, Patricia LauraIcon ; González, CarolinaIcon ; Natale, Maria AilenIcon ; Perrone, Alina ElizabethIcon ; Milduberger, Natalia AyelenIcon ; Laucella, Susana AdrianaIcon ; Bua, Jacqueline ElenaIcon
Fecha de publicación: 01/2021
Editorial: University of Chicago Press
Revista: Journal Of Infectious Diseases
ISSN: 0022-1899
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Inmunología

Resumen

Trypanosoma cruzi, the causative agent of Chagas disease, can be transmitted to the offspring of infected women, which constitutes an epidemiologically significant parasite transmission route in non-endemic areas. It is relevant to evaluate differentially expressed factors in T. cruzi-infected pregnant women as potential markers of Chagas congenital transmission.MethodsCirculating levels of twelve cytokines and chemokines were measured by ELISA or cytometric bead array in T. cruzi-infected and uninfected pregnant women in their second trimester of pregnancy, and control groups of T. cruzi-infected and uninfected non-pregnant women.ResultsT. cruzi-infected women showed a pro-inflammatory Th1-biased profile, with increased levels of TNF-α, IL-12p70, IL-15 and MIG. Uninfected pregnant women presented a biased response towards Th2/Th17/Treg profiles, with increased plasma levels of IL-5, IL-6, IL-1β, IL-17A and IL-10. Finally, we identified that high parasitemia together with low levels of TNF-α, IL-15, and IL-17, low TNF-α/IL-10 ratio, and high IL-12p70 levels are factors associated with an increased probability of Chagas congenital transmission.ConclusionsT. cruzi-infected pregnant women who did not transmit the infection to their babies exhibited a distinct pro-inflammatory cytokine profile that might serve as a potential predictive marker of congenital transmission.
Palabras clave: TRYPANOSOMA CRUZI , PREGNANCY , CYTOKINES , CONGENITAL TRANSMISSION
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/157695
URL: https://academic.oup.com/jid/article-abstract/224/6/1086/6126505
DOI: https://dx.doi.org/10.1093/infdis/jiab057
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Articulos(SEDE CENTRAL)
Articulos de SEDE CENTRAL
Citación
Volta, Bibiana; Bustos, Patricia Laura; González, Carolina; Natale, Maria Ailen; Perrone, Alina Elizabeth; et al.; Circulating cytokine and chemokine profiles of Trypanosoma cruzi-infected women during pregnancy and its association with congenital transmission; University of Chicago Press; Journal Of Infectious Diseases; 2; 6; 1-2021; 1086–1095
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