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dc.contributor.author
Sterin, Leonor Josefina
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dc.contributor.author
Furlan, César
dc.contributor.author
Borda, Enri Santiago
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dc.date.available
2022-05-16T18:20:05Z
dc.date.issued
2009-06
dc.identifier.citation
Sterin, Leonor Josefina; Furlan, César; Borda, Enri Santiago; Autoantibodies to β1-adrenoceptors in human chronic periodontitis induce overexpression of fibroblast CD40 and trigger PGE2 generation; Wiley Blackwell Publishing, Inc; Journal of Periodontal Research; 44; 4; 6-2009; 330-337
dc.identifier.issn
0022-3484
dc.identifier.uri
http://hdl.handle.net/11336/157659
dc.description.abstract
Background and Objective: Autoimmune mechanisms may contribute to the pathogenesis of periodontal disease. Autoantibodies with the potential to bind and activate b1 -adrenoceptors (b1 -AR) of human gingival fibroblasts were studied to provide evidence of altered humoral immune response in chronic periodontal 2disease. Material and Methods: Flow cytometry and enzyme-linked immunosorbent assay using cell culture-adherent gingival fibroblasts and/or their purified membranes and/or a synthetic peptide corresponding to the second extracellular loop of human b1-AR were used to detect serum antibodies. The effects of antibodies from chronic periodontal disease patients on PGE2 generation and CD40 expression were also tested. Results: Circulating immunoglobulin G (IgG) from chronic periodontal disease patients (but not from normal individuals) interacted with the fibroblast surface, 3activating b1-AR. Atenolol or CGP 20712 and b1 synthetic peptide inhibited the 4interaction of IgG with b1-AR. Immunoglobulin G from chronic periodontal disease patients also displayed agonist-like activity associated with specific b1-AR activation, increasing PGE2 generation and CD40 overexpression. The corresponding affinity-purified anti-b1 -AR peptide IgG mimicked these effects. Both effects were prevented by inhibition of cyclo-oxygenase. Conclusion: This article supports the participation of humoral immune alterations in chronic periodontal disease resulting in postsynaptic functional deregulation. Overproduction of proinflammatory mediators (PGE2 and CD40 expression) is induced as a consequence of antibody–b1 -AR interaction. The PGE2–CD40–IgG 5axis may play a part in the pathophysiological mechanisms underlying the inflammatory process in chronic periodontal disease.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Wiley Blackwell Publishing, Inc
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Autoantibodies
dc.subject
b-adrenoceptors
dc.subject
CD40 expression
dc.subject.classification
Inmunología
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dc.subject.classification
Medicina Básica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Autoantibodies to β1-adrenoceptors in human chronic periodontitis induce overexpression of fibroblast CD40 and trigger PGE2 generation
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2022-05-12T06:32:50Z
dc.identifier.eissn
1600-0765
dc.journal.volume
44
dc.journal.number
4
dc.journal.pagination
330-337
dc.journal.pais
Estados Unidos
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dc.journal.ciudad
Hoboken
dc.description.fil
Fil: Sterin, Leonor Josefina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Farmacología; Argentina
dc.description.fil
Fil: Furlan, César. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Farmacología; Argentina
dc.description.fil
Fil: Borda, Enri Santiago. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Farmacología; Argentina
dc.journal.title
Journal of Periodontal Research
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/10.1111/j.1600-0765.2008.01139.x
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1111/j.1600-0765.2008.01139.x
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