Artículo
Inhibition of breast tumor growth by N(G)-nitro-L-arginine methyl ester (L-NAME) is accompanied by activation of fibroblasts
Sciacca, Marianela
; Belgorosky, Denise
; Zambrano, Macarena; Gomez Escalante, José gnacio; Roca, Fernanda; Langle, Yanina Verónica
; Sandes, Eduardo Omar; Lodillinsky, Catalina
; Eijan, Ana Maria
Fecha de publicación:
01/12/2019
Editorial:
Academic Press Inc Elsevier Science
Revista:
Nitric Oxide-Biology and Chemistry
ISSN:
1089-8603
e-ISSN:
1089-8611
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Nitric Oxide (NO) is involved in many physiological and pathological processes. It is generated by a family of NO synthases (NOS), being the inducible isoform, iNOS, responsible for higher amounts of NO. Here, we report that pharmacological inhibition of NO production by L-NAME reduces both viability and MAPK activated signalling pathways in iNOS positive human and murine cancer cell lines. In vivo, using syngeneic models, in parallel with tumor reduction induced by L-NAME, collagen deposition and α-SMA positive stromal cells are observed. This observation takes place only when tumor cells express iNOS. In vitro, L-NAME induces viability and differentiation on fibroblast. Our results reveal that NO inhibition contributes to stimulate proliferation and activation of fibroblasts in parallel with tumor reduction of iNOS positive breast cancer.
Palabras clave:
BREAST CANCER
,
INOS
,
FIBROBLAST
,
L-NAME
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Articulos(OCA HOUSSAY)
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Citación
Sciacca, Marianela; Belgorosky, Denise; Zambrano, Macarena; Gomez Escalante, José gnacio; Roca, Fernanda; et al.; Inhibition of breast tumor growth by N(G)-nitro-L-arginine methyl ester (L-NAME) is accompanied by activation of fibroblasts; Academic Press Inc Elsevier Science; Nitric Oxide-Biology and Chemistry; 93; 1-12-2019; 34-43
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