Mostrar el registro sencillo del ítem
dc.contributor.author
Cunningham, Marla
dc.contributor.author
Vinderola, Celso Gabriel
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.contributor.author
Charalampopoulos, Dimitris
dc.contributor.author
Lebeer, Sarah
dc.contributor.author
Sanders, Mary Ellen
dc.contributor.author
Grimaldi, Roberta
dc.date.available
2022-05-13T14:20:36Z
dc.date.issued
2021
dc.identifier.citation
Cunningham, Marla; Vinderola, Celso Gabriel; Charalampopoulos, Dimitris; Lebeer, Sarah; Sanders, Mary Ellen; et al.; Applying probiotics and prebiotics in new delivery formats – is the clinical evidence transferable?; Elsevier Science London; Trends In Food Science & Technology (regular Ed.); 112; 2021; 495-506
dc.identifier.issn
0924-2244
dc.identifier.uri
http://hdl.handle.net/11336/157469
dc.description.abstract
Background: There is substantial demand for gut health products incorporating probiotics and prebiotics. They are being delivered as ingredients in an increasing range of different product formulations. While new delivery matrices are assessed for their potential impact on cell viability and prebiotic degradation, it is unknown whether they should be expected to independently alter the clinical effect of a given probiotic and prebiotic. Scope and approach: We provide an overview of preclinical and clinical data to examine the degree to which probiotic and prebiotic efficacy may be altered by processing and incorporation into various delivery matrices. We also consider the impact of inter-individual host factors on product efficacy. We further review regulatory positions across the globe on substantiation of prebiotic and probiotic efficacy in the final product format. Key findings and conclusions: In vitro data suggest that the delivery matrix may interact with prebiotic and probiotic functions via various physicochemical interactions with molecular and cellular structures and changes in cellular expression. However, direct evidence to suggest these changes have a significant in vivo impact is very limited. Indeed, meta-analyses suggest a robustness of effect across delivery matrices. Regulatory expectations vary among regions, but scope typically exists for adequate scientific justification to translate probiotic or prebiotic evidence across product formats. Early evidence suggests host factors such as diet, health and microbiome status are likely to play an important role in an individual´s response to a given probiotic and prebiotic.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Science London
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
DELIVERY MATRIX
dc.subject
HOST FACTORS
dc.subject
PREBIOTIC
dc.subject
PROBIOTIC
dc.subject
PRODUCT FORMULATION
dc.subject
REGULATORY
dc.subject.classification
Alimentos y Bebidas
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.subject.classification
Otras Ingenierías y Tecnologías
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.subject.classification
INGENIERÍAS Y TECNOLOGÍAS
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.title
Applying probiotics and prebiotics in new delivery formats – is the clinical evidence transferable?
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2022-05-06T16:18:02Z
dc.journal.volume
112
dc.journal.pagination
495-506
dc.journal.pais
Reino Unido
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.journal.ciudad
Londres
dc.description.fil
Fil: Cunningham, Marla. No especifíca;
dc.description.fil
Fil: Vinderola, Celso Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Lactología Industrial. Universidad Nacional del Litoral. Facultad de Ingeniería Química. Instituto de Lactología Industrial; Argentina
dc.description.fil
Fil: Charalampopoulos, Dimitris. University of Reading; Reino Unido
dc.description.fil
Fil: Lebeer, Sarah. Universiteit Antwerp; Bélgica
dc.description.fil
Fil: Sanders, Mary Ellen. International Scientific Association For Probiotics And Prebiotics; Estados Unidos
dc.description.fil
Fil: Grimaldi, Roberta. No especifíca;
dc.journal.title
Trends In Food Science & Technology (regular Ed.)
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.tifs.2021.04.009
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0924224421002612?via%3Dihub
Archivos asociados