Artículo
Should we listen to our clock to prevent type 2 diabetes mellitus?
Karthikeyan, Ramanujam; Marimuthu, Ganapathy; Spence, David Warren; Pandi Perumal, Seithikurippu R.; BaHammam, Ahmed S.; Brown, Gregory M.; Cardinali, Daniel Pedro
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Fecha de publicación:
11/2014
Editorial:
Elsevier Ireland
Revista:
Diabetes Research and Clinical Practice
ISSN:
0168-8227
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
The circadian clock drives a number of metabolic processes including energy intake, storage and utilization coupled with the sleep/wake cycles. Globally, the increasing prevalence of type 2 diabetes (T2DM) has become a significant international public health concern. In view of the heavy societal burden caused by diabetes, and further, to reduce its growing incidence, it is clearly essential to understand the causes of this disease and to devise more effective strategies for its treatment. Although many factors cause T2DM, this article centers on the role of circadian regulation of metabolism. The correlation between the increased occurrence of T2DM and the ubiquity of modern social pressures such as 24/7 lifestyles as well as nocturnal lighting conditions point strongly to the hypothesis that malfunctioning of circadian controls may be involved in the etiology of the illness. Nocturnal light exposure, unusual timing of food, irregular sleep/wake schedules and traveling between different time zones are some of the factors responsible for improper entrainment of the clock. Recent reports have proposed that strengthening of circadian clock functioning and proper timing of food intake could stabilize glucose homeostasis. This strategy thus represents a chronotherapeutic option for non-pharmaceutical intervention in treating T2DM patients.
Palabras clave:
Circadian Rhythms
,
Clock Genes
,
Melatonin
,
Metabolism
,
Type 2 Diabetes Mellitus
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Articulos(OCA HOUSSAY)
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Citación
Karthikeyan, Ramanujam; Marimuthu, Ganapathy; Spence, David Warren; Pandi Perumal, Seithikurippu R.; BaHammam, Ahmed S.; et al.; Should we listen to our clock to prevent type 2 diabetes mellitus?; Elsevier Ireland; Diabetes Research and Clinical Practice; 106; 2; 11-2014; 182-190
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