Mostrar el registro sencillo del ítem
dc.contributor.author
Tomosada, Yohsuke
dc.contributor.author
Villena, Julio Cesar
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.contributor.author
Morata, Kozue
dc.contributor.author
Chiba, Eriko
dc.contributor.author
Shimazu, Yomoyuki
dc.contributor.author
Aso, Hisashi
dc.contributor.author
Iwabuchi, Norisuke
dc.contributor.author
Xiao, Jin-Zhong
dc.contributor.author
Saito, Tadao
dc.contributor.author
Kitazawa, Haruki
dc.date.available
2015-08-07T14:30:26Z
dc.date.issued
2013-03
dc.identifier.citation
Tomosada, Yohsuke; Villena, Julio Cesar; Morata, Kozue; Chiba, Eriko; Shimazu, Yomoyuki; et al.; Immunoregulatory effect of bifidobacteria strains in porcine intestinal epithelial cells trough modulation of ubiquitin-editing enzyme A20 expression; Public Library Science; Plos One; 8; 3; 3-2013; 59259-59270
dc.identifier.issn
1932-6203
dc.identifier.uri
http://hdl.handle.net/11336/1573
dc.description.abstract
Background: We previously showed that evaluation of anti-inflammatory activities of lactic acid bacteria in porcine intestinal epithelial (PIE) cells is useful for selecting potentially immunobiotic strains. Objective: The aims of the present study were: i) to select potentially immunomodulatory bifidobacteria that beneficially modulate the Toll-like receptor (TLR)-4-triggered inflammatory response in PIE cells and; ii) to gain insight into the molecular mechanisms involved in the anti-inflammatory effect of immunobiotics by evaluating the role of TLR2 and TLR negative regulators in the modulation of proinflammatory cytokine production and activation of mitogen-activated protein kinase (MAPK) and nuclear factor-kB (NF-kB) pathways in PIE cells. Results: Bifidobacteria longum BB536 and B. breve M-16V strains significantly downregulated levels of interleukin (IL)-8, monocyte chemotactic protein (MCP)-1 and IL-6 in PIE cells challenged with heat-killed enterotoxigenic Escherichia coli. Moreover, BB536 and M-16V strains attenuated the proinflammatory response by modulating the NF-kB and MAPK pathways. In addition, our findings provide evidence for a key role for the ubiquitin-editing enzyme A20 in the anti- inflammatory effect of immunobiotic bifidobacteria in PIE cells. Conclusions: We show new data regarding the mechanism involved in the anti-inflammatory effect of immunobiotics. Several strains with immunoregulatory capabilities used a common mechanism to induce tolerance in PIE cells. Immunoregulatory strains interacted with TLR2, upregulated the expression of A20 in PIE cells, and beneficially modulated the subsequent TLR4 activation by reducing the activation of MAPK and NF-kB pathways and the production of proinflammatory cytokines. We also show that the combination of TLR2 activation and A20 induction can be used as biomarkers to screen and select potential immunoregulatory bifidobacteria strains.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Public Library Science
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Bifidobacteria
dc.subject
Porcine Intestinal Epithelial Cells
dc.subject
A20
dc.subject
Immunoregulation
dc.subject.classification
Inmunología
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.subject.classification
Medicina Básica
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.subject.classification
Producción Animal y Lechería
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.subject.classification
Producción Animal y Lechería
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.subject.classification
CIENCIAS AGRÍCOLAS
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.title
Immunoregulatory effect of bifidobacteria strains in porcine intestinal epithelial cells trough modulation of ubiquitin-editing enzyme A20 expression
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-03-30 10:35:44.97925-03
dc.journal.volume
8
dc.journal.number
3
dc.journal.pagination
59259-59270
dc.journal.pais
Estados Unidos
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.journal.ciudad
San Francisco
dc.description.fil
Fil: Tomosada, Yohsuke. Tohoku University; Japón;
dc.description.fil
Fil: Villena, Julio Cesar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico - CONICET - Tucumán. Centro de Referencia Para Lactobacilos (i); Argentina;
dc.description.fil
Fil: Morata, Kozue. Tohoku University; Japón;
dc.description.fil
Fil: Chiba, Eriko. Tohoku University; Japón;
dc.description.fil
Fil: Shimazu, Yomoyuki. Tohoku University; Japón;
dc.description.fil
Fil: Aso, Hisashi. Tohoku University; Japón;
dc.description.fil
Fil: Iwabuchi, Norisuke. Morinaga Milk Industry Co. Ltd.; Japón;
dc.description.fil
Fil: Xiao, Jin-Zhong. Morinaga Milk Industry Co. Ltd.; Japón;
dc.description.fil
Fil: Saito, Tadao. Tohoku University; Japón;
dc.description.fil
Fil: Kitazawa, Haruki. Tohoku University; Japón;
dc.journal.title
Plos One
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1371/journal.pone.0059259
Archivos asociados