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dc.contributor.author
Karthikeyan, Ramanujam
dc.contributor.author
Marimuthu, Ganapathy
dc.contributor.author
Sooriyakumar, Murugesan
dc.contributor.author
BaHammam, Ahmed S.
dc.contributor.author
Spence, David Warren
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Pandi Perumal, Seithikurippu R.
dc.contributor.author
Brown, Gregory M.
dc.contributor.author
Cardinali, Daniel Pedro
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dc.date.available
2017-04-26T17:39:32Z
dc.date.issued
2014-06
dc.identifier.citation
Karthikeyan, Ramanujam; Marimuthu, Ganapathy; Sooriyakumar, Murugesan; BaHammam, Ahmed S.; Spence, David Warren; et al.; Per3 length polymorphism in patients with type 2 diabetes mellitus; De Gruyter; Hormone Molecular Biology and Clinical Investigation; 18; 3; 6-2014; 145-149
dc.identifier.issn
1868-1883
dc.identifier.uri
http://hdl.handle.net/11336/15739
dc.description.abstract
BACKGROUND: A number of observations support the involvement of circadian clock genes in the regulation of metabolic processes. One of these circadian genes, Per3, exhibits a variable number tandem repeat length polymorphism, consisting of two alleles, namely four and five repeat alleles, in its exon 18. The objective of this study was to examine the existence of Per3 variants in patients with type 2 diabetes mellitus (T2DM) as compared to a non T2DM control group. METHODS: Intravenous blood samples were collected to obtain white blood cells from 302 T2DM patients and 330 non-diabetic, age- and sex-matched, individuals. Per3 genotyping was performed on DNA by polymerase chain reaction. RESULTS: Frequency of five repeat allele was higher, and that of four repeat allele lower, in T2DM patients as compared to non-diabetic controls (χ2=6.977, p=0.0082) CONCLUSIONS: The results indicate an association of Per3 five repeat allele with T2DM occurrence and suggest that individuals with five repeat allele may be at a greater risk for T2DM as compared to those carrying the four repeat allele.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
De Gruyter
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Circadian Rhythms
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Clock Gene
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Metabolism
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Per3 Polymorphism
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Type 2 Diabetes Mellitus
dc.subject.classification
Fisiología
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dc.subject.classification
Medicina Básica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Per3 length polymorphism in patients with type 2 diabetes mellitus
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-04-26T14:13:16Z
dc.journal.volume
18
dc.journal.number
3
dc.journal.pagination
145-149
dc.journal.pais
Alemania
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dc.journal.ciudad
Berlín
dc.description.fil
Fil: Karthikeyan, Ramanujam. Madurai Kamaraj University. School of Biological Sciences. Department of Animal Behaviour and Physiology; India
dc.description.fil
Fil: Marimuthu, Ganapathy. Madurai Kamaraj University. School of Biological Sciences. Department of Animal Behaviour and Physiology; India
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Fil: Sooriyakumar, Murugesan. Madurai Medical College. Department of Medicine; India
dc.description.fil
Fil: BaHammam, Ahmed S.. King Saud University. College of Medicine; Arabia Saudita
dc.description.fil
Fil: Spence, David Warren.
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Fil: Pandi Perumal, Seithikurippu R.. Somnogen Canada; Canadá
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Fil: Brown, Gregory M.. University of Toronto; Canadá
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Fil: Cardinali, Daniel Pedro. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Facultad de Ciencias Médicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.journal.title
Hormone Molecular Biology and Clinical Investigation
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1515/hmbci-2013-0049
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.degruyter.com/view/j/hmbci.2014.18.issue-3/hmbci-2013-0049/hmbci-2013-0049.xml
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