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Artículo

Exposure to glyphosate during pregnancy induces neurobehavioral alterations and downregulation of Wnt5a-CaMKII pathway

Coullery, Romina PaolaIcon ; Pacchioni, Alejandra MariaIcon ; Rosso, Silvana BeatrizIcon
Fecha de publicación: 09/2020
Editorial: Pergamon-Elsevier Science Ltd
Revista: Reproductive Toxicology
ISSN: 0890-6238
e-ISSN: 1873-1708
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Toxicología

Resumen

Glyphosate-based formulations are the most popular herbicide used around the world. These herbicides are widely applied in agriculture to control weeds on genetically modified crops. Although there is much evidence showing that glyphosate-based herbicides induce toxic effect on reproductive and hepatic systems, and also cause oxidative damage on cells, studies from recent years revealed that the nervous system may represent a key target for their toxicity. In the present work, we evaluated the effect of glyphosate (without adjuvants) in neonate rats after gestational exposure. Particularly, we examined whether glyphosate during gestation affected the nervous system function at early development. Pregnant Wistar rats were treated with 24 or 35 mg/kg of pure glyphosate every 48 h and neurobehavioral studies were performed. Our results indicated that gestational exposure to glyphosate induced changes in reflexes development, motor activity and cognitive function, in a dose-dependent manner. To go further, we evaluated whether prenatal exposure to glyphosate affected the Ca+2-mediated Wnt non-canonical signaling pathway. Results indicated that embryos exposed to glyphosate showed an inhibition of Wnt5a-CaMKII signaling pathway, an essential cascade controlling the formation and integration of neural cir-cuits. Taken together, these findings suggest that gestational exposure to glyphosate leads to a downregulation of Wnt/Ca+2 pathway that could induce a developmental neurotoxicity evidenced by deficits at behavioral and cognitive levels in rat pups.
Palabras clave: GLYPHOSATE , BEHAVIOR , PRENATAL-EXPOSURE , WNT
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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/157302
URL: https://www.sciencedirect.com/science/article/abs/pii/S0890623820301945
DOI: https://doi.org/10.1016/j.reprotox.2020.08.006
Colecciones
Articulos(CCT - ROSARIO)
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - ROSARIO
Citación
Coullery, Romina Paola; Pacchioni, Alejandra Maria; Rosso, Silvana Beatriz; Exposure to glyphosate during pregnancy induces neurobehavioral alterations and downregulation of Wnt5a-CaMKII pathway; Pergamon-Elsevier Science Ltd; Reproductive Toxicology; 96; 9-2020; 390-398
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