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dc.contributor.author
Axelrud, Luiza Kvitko
dc.contributor.author
Sato, João Ricardo
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Santoro, Marcos Leite
dc.contributor.author
Talarico, Fernanda
dc.contributor.author
Pine, Daniel Samuel
dc.contributor.author
Rohde, Luis Augusto
dc.contributor.author
Zugman, Andre
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Amaro Junior, Edson
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Affonseca Bressan, Rodrigo
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Grassi Oliveira, Rodrigo
dc.contributor.author
Pan, Pedro Mario
dc.contributor.author
Scopel Hoffmann, Maurício
dc.contributor.author
Simioni, Andre Rafael
dc.contributor.author
Guinjoan, Salvador Martín
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Hakonarson, Hakon
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Brietzke, Elisa
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Gadelha, Ary
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Pellegrino da Silva, Renata
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Queiroz Hoexter, Marcelo
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Miguel, Euripedes Constantino
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Iole Belangero, Sintia
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Abrahão Salum, Giovanni
dc.date.available
2022-05-11T10:55:52Z
dc.date.issued
2019-10
dc.identifier.citation
Axelrud, Luiza Kvitko; Sato, João Ricardo; Santoro, Marcos Leite; Talarico, Fernanda; Pine, Daniel Samuel; et al.; Genetic risk for Alzheimer's disease and functional brain connectivity in children and adolescents; Elsevier Science Inc.; Neurobiology of Aging; 82; 10-2019; 10-17
dc.identifier.issn
0197-4580
dc.identifier.uri
http://hdl.handle.net/11336/157170
dc.description.abstract
Research suggested accumulation of tau proteins might lead to the degeneration of functional networks. Studies investigating the impact of genetic risk for Alzheimer’s disease (AD) on early brain connections might shed light on mechanisms leading to AD development later in life. Here, we aim to investigate whether the polygenic risk score for Alzheimer’s disease (AD-PRS) influences the connectivity among regions susceptible to tau pathology during childhood and adolescence. Participants were youth, aged 6 e14 years, and recruited in Porto Alegre (discovery sample, n ¼ 332) and São Paulo (replication sample, n ¼ 304), Brazil. Subjects underwent genotyping and 6-min resting state funcional magnetic resonance imaging. Connections between the local maxima of tau pathology networks were used as dependent variables. The AD-PRS was associated with the connectivity between the right precuneus and the right superior temporal gyrus (discovery sample: b ¼ 0.180, padjusted ¼ 0.036; replication sample: b ¼ 0.202, p ¼ 0.031). This connectivity was also associated with inhibitory control (b ¼ 0.157, padjusted ¼ 0.035) and moderated the association between the AD-PRS and both immediate and delayed recall. These findings suggest the AD-PRS may affect brain connectivity in youth, which might impact memory performance and inhibitory control in early life.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Science Inc.
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
ALZHEIMER´S DISEASE
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POLYGENIC RISK SCORES
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TAU PROTEIN
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FUNCTIONAL CONNECTIVITY
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Psiquiatría
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Medicina Clínica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Genetic risk for Alzheimer's disease and functional brain connectivity in children and adolescents
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2022-04-21T16:27:31Z
dc.journal.volume
82
dc.journal.pagination
10-17
dc.journal.pais
Estados Unidos
dc.description.fil
Fil: Axelrud, Luiza Kvitko. Universidade Federal de Sao Paulo; Brasil
dc.description.fil
Fil: Sato, João Ricardo. Universidade Federal de Sao Paulo; Brasil
dc.description.fil
Fil: Santoro, Marcos Leite. Universidade Federal de Sao Paulo; Brasil
dc.description.fil
Fil: Talarico, Fernanda. Universidade Federal de Sao Paulo; Brasil
dc.description.fil
Fil: Pine, Daniel Samuel. Universidade Federal de Sao Paulo; Brasil
dc.description.fil
Fil: Rohde, Luis Augusto. Universidade Federal de Sao Paulo; Brasil
dc.description.fil
Fil: Zugman, Andre. Universidade Federal de Sao Paulo; Brasil
dc.description.fil
Fil: Amaro Junior, Edson. Universidade Federal de Sao Paulo; Brasil
dc.description.fil
Fil: Affonseca Bressan, Rodrigo. Universidade Federal de Sao Paulo; Brasil
dc.description.fil
Fil: Grassi Oliveira, Rodrigo. Universidade Federal de Sao Paulo; Brasil
dc.description.fil
Fil: Pan, Pedro Mario. Universidade Federal de Sao Paulo; Brasil
dc.description.fil
Fil: Scopel Hoffmann, Maurício. Universidade Federal de Sao Paulo; Brasil
dc.description.fil
Fil: Simioni, Andre Rafael. Universidade Federal de Sao Paulo; Brasil
dc.description.fil
Fil: Guinjoan, Salvador Martín. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad de Buenos Aires; Argentina
dc.description.fil
Fil: Hakonarson, Hakon. Universidade Federal de Sao Paulo; Brasil
dc.description.fil
Fil: Brietzke, Elisa. Universidade Federal de Sao Paulo; Brasil
dc.description.fil
Fil: Gadelha, Ary. Universidade Federal de Sao Paulo; Brasil
dc.description.fil
Fil: Pellegrino da Silva, Renata. Universidade Federal de Sao Paulo; Brasil
dc.description.fil
Fil: Queiroz Hoexter, Marcelo. Universidade Federal de Sao Paulo; Brasil
dc.description.fil
Fil: Miguel, Euripedes Constantino. Universidade Federal de Sao Paulo; Brasil
dc.description.fil
Fil: Iole Belangero, Sintia. Universidade Federal de Sao Paulo; Brasil
dc.description.fil
Fil: Abrahão Salum, Giovanni. Universidade Federal de Sao Paulo; Brasil
dc.journal.title
Neurobiology of Aging
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S0197458019301939
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.neurobiolaging.2019.06.011
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