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dc.contributor.author
Herrera, Melina Elizabeth
dc.contributor.author
Di Gregorio, Sabrina Noelia
dc.contributor.author
Haim, Maria Sol
dc.contributor.author
Posse, Graciela Raquel
dc.contributor.author
Mollerach, Marta Eugenia
dc.contributor.author
Di Conza, José Alejandro
dc.date.available
2022-05-06T17:54:55Z
dc.date.issued
2021-04
dc.identifier.citation
Herrera, Melina Elizabeth; Di Gregorio, Sabrina Noelia; Haim, Maria Sol; Posse, Graciela Raquel; Mollerach, Marta Eugenia; et al.; Genetic changes associated with tigecycline resistance in Staphylococcus aureus in vitro-selected mutants belonging to different lineages; Elsevier Science; International Journal of Antimicrobial Agents; 57; 4; 4-2021; 1-7
dc.identifier.issn
0924-8579
dc.identifier.uri
http://hdl.handle.net/11336/156827
dc.description.abstract
Tigecycline (TGC) resistance remains rare in Staphylococcus aureus worldwide. In this study, 12 TGCresistant S. aureus mutants (TRSAm) were obtained displaying an increase in efflux activity. The isolates belonged to seven different genetic lineages, with a predominance of clonal complex 5 (CC5). Diverse genetic changes in mepA and mepR genes were found producing alterations in the amino acid sequences of the corresponding proteins (MepA and MepR, respectively). The most frequent amino acid change in MepA was Glu287Gly. All of the TRSAm exhibited different single nucleotide polymorphisms (SNPs) or insertions/deletions (InDels) in mepR causing premature stop codons or amino acid changes in MepR. Expression of mepA was significantly increased in TRSAm with different mutations in mepA and mepR. Of the 12 TRSAm, 6 also harboured mutations in rpsJ that resulted in amino acid changes in the S10 ribosomal protein, with Lys57 being the most frequently mutated site. Our findings demonstrate that these acquired mechanisms of TGC resistance are not restricted to a single type of genotypic background and that different lineages might have the same plasticity to develop TGC resistance. The impact of TGC selective pressure assessed by whole-genome sequencing in four selected strain pairs revealed mutations in other singular genes and IS256 mobilisation.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Science
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
MEPA
dc.subject
MEPR
dc.subject
RPSJ
dc.subject
STAPHYLOCOCCUS AUREUS
dc.subject
TIGECYCLINE RESISTANCE
dc.subject.classification
Enfermedades Infecciosas
dc.subject.classification
Ciencias de la Salud
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Genetic changes associated with tigecycline resistance in Staphylococcus aureus in vitro-selected mutants belonging to different lineages
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2022-04-21T16:26:40Z
dc.identifier.eissn
1872-7913
dc.journal.volume
57
dc.journal.number
4
dc.journal.pagination
1-7
dc.journal.pais
Países Bajos
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Herrera, Melina Elizabeth. Universidad Adventista del Plata. Facultad de Ciencias de la Salud; Argentina
dc.description.fil
Fil: Di Gregorio, Sabrina Noelia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Investigaciones en Bacteriología y Virología Molecular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
dc.description.fil
Fil: Haim, Maria Sol. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Investigaciones en Bacteriología y Virología Molecular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
dc.description.fil
Fil: Posse, Graciela Raquel. Universidad Adventista del Plata. Facultad de Ciencias de la Salud; Argentina. Sanatorio Adventista del Plata; Argentina
dc.description.fil
Fil: Mollerach, Marta Eugenia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Investigaciones en Bacteriología y Virología Molecular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
dc.description.fil
Fil: Di Conza, José Alejandro. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Investigaciones en Bacteriología y Virología Molecular; Argentina. Universidad Adventista del Plata. Facultad de Ciencias de la Salud; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
dc.journal.title
International Journal of Antimicrobial Agents
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0924857921000340
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1016/j.ijantimicag.2021.106304
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