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dc.contributor.author
Prado, Natalia Jorgelina
dc.contributor.author
Segovia Roldan, Margarita
dc.contributor.author
Diez, Emiliano Raúl
dc.contributor.author
Pueyo, Esther
dc.contributor.other
Vlachou, Marilena
dc.date.available
2022-05-06T15:50:53Z
dc.date.issued
2020
dc.identifier.citation
Prado, Natalia Jorgelina; Segovia Roldan, Margarita; Diez, Emiliano Raúl; Pueyo, Esther; Melatonin for a Healthy Heart Rhythm; IntechOpen; 2020; 1-29
dc.identifier.isbn
978-1-83962-909-9
dc.identifier.uri
http://hdl.handle.net/11336/156799
dc.description.abstract
Melatonin is a promising cardioprotective agent. Its increase during the night is associated with healthy cardiovascular function. On the other hand, reduced levels of melatonin are related to diseases. Aging and chronodisruptors reduce melatonin levels. Pharmacological supplementation reduces the deleterious effects of cardiovascular risk factors and improves the myocardial response to ischemia/reperfusion injury and other proarrhythmic conditions. The protective mechanisms of melatonin involve its antioxidant properties as well as receptor-mediated actions. Signaling pathways include membrane responses, cytoplasmic modulation of kinases, nuclear receptor interactions, and improvement of mitochondrial functions. This chapter focuses on the electrophysiological and the antiarrhythmic properties of melatonin. The acute and chronic protective mechanisms of melatonin will be analyzed with an emphasis on transmembrane potentials and intercellular communication. An outstanding antifibrillatory effect makes melatonin a novel antiarrhythmic agent worthy of further exploration in the path to clinical applications.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
IntechOpen
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
melatonin
dc.subject
arrhythmias
dc.subject
ventricular fibrillation
dc.subject
action potential
dc.subject.classification
Fisiología
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Melatonin for a Healthy Heart Rhythm
dc.type
info:eu-repo/semantics/publishedVersion
dc.type
info:eu-repo/semantics/bookPart
dc.type
info:ar-repo/semantics/parte de libro
dc.date.updated
2021-11-08T17:52:26Z
dc.journal.pagination
1-29
dc.journal.pais
Reino Unido
dc.journal.ciudad
Londres
dc.description.fil
Fil: Prado, Natalia Jorgelina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
dc.description.fil
Fil: Segovia Roldan, Margarita. Universidad de Zaragoza; España
dc.description.fil
Fil: Diez, Emiliano Raúl. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
dc.description.fil
Fil: Pueyo, Esther. Universidad de Zaragoza; España
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.intechopen.com/chapters/71266
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.5772/intechopen.91447
dc.conicet.paginas
29
dc.source.titulo
Melatonin: The Hormone of Darkness and its Therapeutic Potential and Perspectives
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