Alloxan diabetes in dogs with renal pedicles clamped

Abstract

Jimenez Diaz, Grande Covian and De Oyal have reported that in dogs in which the vessels of both kidneys were clamped, the intravenous injection of alloxan in doses of 80-100 mgm./kgm. failed to produce either the hyperglycemia or uremia observed in controls in which the clamping was omitted. They postulated that "contact between alloxan and the kidney is apparently necessary for the display of the full diabetogenic effect". However, diabetes was observed on injecting alloxan during clamping of both renal pedicles in rats2,3 and rabbits'. Recently, Jimenez Diaz and Souto Candeira postulated that "alloxan produces some kind of renal injury which accentuates diabetes. . . . In conclusion, the kidney is apparently not necessary for the production of alloxan diabetes, but renal injury produced by alloxan would contribute to accentuate it."