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dc.contributor.author
Daray, Federico Manuel
dc.contributor.author
Grendas, Leandro Nicolás
dc.contributor.author
Rodante, Demián
dc.contributor.author
Errasti, Andrea Emilse
dc.contributor.author
Cases, Gabriel Guillermo
dc.contributor.author
Moix, Claudio F.
dc.contributor.author
Uicich, Raúl Eduardo
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Giménez, María Isabel
dc.contributor.author
Puppo, Soledad
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Fasolino, Gerardo H.
dc.contributor.author
Portela, Alicia Andrea
dc.contributor.author
Galfalvy, Hanga C.
dc.contributor.author
Sublette, M. Elizabeth
dc.date.available
2022-05-02T15:01:57Z
dc.date.issued
2021-02
dc.identifier.citation
Daray, Federico Manuel; Grendas, Leandro Nicolás; Rodante, Demián; Errasti, Andrea Emilse; Cases, Gabriel Guillermo; et al.; Polyunsaturated fatty acids as predictors of future suicide attempt; Elsevier; Prostaglandins Leukotrienes and Essential Fatty Acids; 165; 2-2021; 1-6
dc.identifier.issn
0952-3278
dc.identifier.uri
http://hdl.handle.net/11336/156222
dc.description.abstract
Polyunsaturated fatty acids (PUFAs) and cholesterol are lipids implicated in suicide risk. We prospectively studied plasma glycerophospholipid PUFAs and cholesterol as putative predictors of suicide attempts. In a multicenter cohort study, we enrolled 123 patients admitted to the emergency department (ED) for suicidal ideation or suicide attempt. Clinical assessments were performed, with follow-up telephone evaluations 6, 12, 18, and 24 months later. Blood samples were obtained in the ED and assayed for PUFAs. Using survival analysis, suicide events were not predicted by eicosapentaenoic acid (EPA, HR: -0.83, 95%CI: 0.39?1.76, p = 0.621) or docosahexaenoic acid (DHA, HR: -0.60, 95%CI: 0.19?1.86, p = 0.371). However, higher arachidonic acid (AA) was a trend for a protective factor (HR=0.30, 95%CI: 0.08?1.08, p = 0.065) in the entire trans-diagnostic sample. This protective effect was significant in all participants with a prior suicide attempt history (n = 85; HR=0.16, 95%CI: 0.04?0.67, p = 0.012), and in the subgroup of attempters with major depressive disorder (MDD; n = 55, HR=0.15, 95%CI:0.03?0.76, p = 0.002). Total LDL- and HDL-cholesterol did not predict subsequent suicide events. AA, but not DHA or EPA, positively correlated with baseline depression severity in MDD patients (r = 0.3, p = 0.006). Contrary to our hypothesis that low n-3 PUFA levels would create risk, we found that while higher AA was associated with greater depression severity at baseline, low AA unexpectedly predicted subsequent suicide attempts, the more so in higher-risk patients. Although surprising, this result agrees with a minority of reports concerning n-6 PUFAs and may represent complex interactions with sample characteristics.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
SUICIDE
dc.subject
PUFAS
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ARACHIDONIC ACID
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MDD
dc.subject.classification
Psiquiatría
dc.subject.classification
Medicina Clínica
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Polyunsaturated fatty acids as predictors of future suicide attempt
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2022-04-26T17:06:38Z
dc.journal.volume
165
dc.journal.pagination
1-6
dc.journal.pais
Países Bajos
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Daray, Federico Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina
dc.description.fil
Fil: Grendas, Leandro Nicolás. Universidad de Buenos Aires. Facultad de Medicina; Argentina
dc.description.fil
Fil: Rodante, Demián. Universidad de Buenos Aires. Facultad de Medicina; Argentina
dc.description.fil
Fil: Errasti, Andrea Emilse. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina
dc.description.fil
Fil: Cases, Gabriel Guillermo. Hospital Italiano; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Moix, Claudio F.. Hospital Italiano; Argentina
dc.description.fil
Fil: Uicich, Raúl Eduardo. Hospital Italiano; Argentina
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Fil: Giménez, María Isabel. Hospital Italiano; Argentina
dc.description.fil
Fil: Puppo, Soledad. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
dc.description.fil
Fil: Fasolino, Gerardo H.. Gobierno de la Ciudad de Buenos Aires. Hospital Municipal "José Tiburcio Borda"; Argentina
dc.description.fil
Fil: Portela, Alicia Andrea. Gobierno de la Ciudad de Buenos Aires. Hospital Municipal "José Tiburcio Borda"; Argentina
dc.description.fil
Fil: Galfalvy, Hanga C.. Columbia University; Estados Unidos
dc.description.fil
Fil: Sublette, M. Elizabeth. Columbia University; Estados Unidos
dc.journal.title
Prostaglandins Leukotrienes and Essential Fatty Acids
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0952327821000107?via%3Dihub
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.plefa.2021.102247
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