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dc.contributor.author
Ruiz Ciancio, Dario Ezequiel
dc.contributor.author
Vargas López, Mauricio Rubén
dc.contributor.author
Thiel, William H.
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Bruno, Martin A.
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Giangrande, Paloma H.
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Mestre, María Belén
dc.date.available
2022-05-02T13:42:09Z
dc.date.issued
2018-09
dc.identifier.citation
Ruiz Ciancio, Dario Ezequiel; Vargas López, Mauricio Rubén; Thiel, William H.; Bruno, Martin A.; Giangrande, Paloma H.; et al.; Aptamers as Diagnostic Tools in Cancer; Multidisciplinary Digital Publishing Institute; Pharmaceuticals; 11; 3; 9-2018; 1-23
dc.identifier.issn
1424-8247
dc.identifier.uri
http://hdl.handle.net/11336/156207
dc.description.abstract
Cancer is the second leading cause of death worldwide. Researchers have been working hard on investigating not only improved therapeutics but also on early detection methods, both critical to increasing treatment efficacy, and developing methods for disease prevention. The use of nucleic acids, or aptamers, has emerged as more specific and accurate cancer diagnostic and therapeutic tools. Aptamers are single-stranded DNA or RNA molecules that recognize specific targets based on unique three-dimensional conformations. Despite the fact aptamer development has been mainly restricted to laboratory settings, the unique attributes of these molecules suggest their high potential for clinical advances in cancer detection. Aptamers can be selected for a wide range of targets, and also linked with an extensive variety of diagnostic agents, via physical or chemical conjugation, to improve previously-established detection methods or to be used as novel biosensors for cancer diagnosis. Consequently, herein we review the principal considerations and recent updates in cancer detection and imaging through aptamer-based molecules.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Multidisciplinary Digital Publishing Institute
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/
dc.subject
APTAMER
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CANCER
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DIAGNOSIS
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IMAGING
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Oncología
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Medicina Clínica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Aptamers as Diagnostic Tools in Cancer
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2022-04-26T16:47:48Z
dc.journal.volume
11
dc.journal.number
3
dc.journal.pagination
1-23
dc.journal.pais
Suiza
dc.journal.ciudad
Basilea
dc.description.fil
Fil: Ruiz Ciancio, Dario Ezequiel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan; Argentina. Universidad Católica de Cuyo - Sede San Juan. Facultad de Ciencias Médicas. Departamento de Neurociencia; Argentina
dc.description.fil
Fil: Vargas López, Mauricio Rubén. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan; Argentina. Universidad Católica de Cuyo - Sede San Juan. Facultad de Ciencias Médicas. Departamento de Neurociencia; Argentina
dc.description.fil
Fil: Thiel, William H.. University of Iowa; Estados Unidos
dc.description.fil
Fil: Bruno, Martin A.. Universidad Católica de Cuyo - Sede San Juan. Facultad de Ciencias Médicas. Departamento de Neurociencia; Argentina
dc.description.fil
Fil: Giangrande, Paloma H.. University of Iowa; Estados Unidos
dc.description.fil
Fil: Mestre, María Belén. Universidad Católica de Cuyo - Sede San Juan. Facultad de Ciencias Médicas. Departamento de Neurociencia; Argentina
dc.journal.title
Pharmaceuticals
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.mdpi.com/1424-8247/11/3/86
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3390/ph11030086
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