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dc.contributor.author
Clevenger, Josh P.
dc.contributor.author
Van Houten, Jason
dc.contributor.author
Blackwood, Michelle
dc.contributor.author
Rodríguez, Gustavo Rubén
dc.contributor.author
Jikumaru, Yusuke
dc.contributor.author
Kamiya, Yuji
dc.contributor.author
Kusano, Miyako
dc.contributor.author
Saito, Kazuki
dc.contributor.author
Visa, Sofia
dc.contributor.author
Van Der Knaap, Esther
dc.date.available
2017-04-21T20:47:45Z
dc.date.issued
2015-07
dc.identifier.citation
Clevenger, Josh P.; Van Houten, Jason; Blackwood, Michelle; Rodríguez, Gustavo Rubén; Jikumaru, Yusuke; et al.; Network analyses reveal shifts in transcript profiles and metabolites that accompany the expression of sun and an elongated tomato fruit; American Society Of Plant Biologist; Plant Physiology; 168; 3; 7-2015; 1164-1178
dc.identifier.issn
0032-0889
dc.identifier.uri
http://hdl.handle.net/11336/15607
dc.description.abstract
SUN controls elongated tomato (Solanum lycopersicum) shape early in fruit development through changes in cell number along the different axes of growth. The gene encodes a member of the IQ domain family characterized by a calmodulin binding motif. To gain insights into the role of SUN in regulating organ shape, we characterized genome-wide transcriptional changes and metabolite and hormone accumulation after pollination and fertilization in wild-type and SUN fruit tissues. Pericarp, seed/placenta, and columella tissues were collected at 4, 7, and 10 d post anthesis. Pairwise comparisons between SUN and the wild type identified 3,154 significant differentially expressed genes that cluster in distinct gene regulatory networks. Gene regulatory networks that were enriched for cell division, calcium/transport, lipid/hormone, cell wall, secondary metabolism, and patterning processes contributed to profound shifts in gene expression in the different fruit tissues as a consequence of high expression of SUN. Promoter motif searches identified putative cis-elements recognized by known transcription factors and motifs related to mitotic-specific activator sequences. Hormone levels did not change dramatically, but some metabolite levels were significantly altered, namely participants in glycolysis and the tricarboxylic acid cycle. Also, hormone and primary metabolite networks shifted in SUN compared with wild-type fruit. Our findings imply that SUN indirectly leads to changes in gene expression, most strongly those involved in cell division, cell wall, and patterningrelated processes. When evaluating global coregulation in SUN fruit, the main node represented genes involved in calcium-regulated processes, suggesting that SUN and its calmodulin binding domain impact fruit shape through calcium signaling.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
American Society Of Plant Biologist
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Solanum Lycopersicum
dc.subject
Fruit Shape
dc.subject
Fruit Development
dc.subject
Signaling
dc.subject.classification
Biología del Desarrollo
dc.subject.classification
Ciencias Biológicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
Network analyses reveal shifts in transcript profiles and metabolites that accompany the expression of sun and an elongated tomato fruit
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-02-23T13:55:09Z
dc.journal.volume
168
dc.journal.number
3
dc.journal.pagination
1164-1178
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Rockville
dc.description.fil
Fil: Clevenger, Josh P..
dc.description.fil
Fil: Van Houten, Jason.
dc.description.fil
Fil: Blackwood, Michelle.
dc.description.fil
Fil: Rodríguez, Gustavo Rubén. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Jikumaru, Yusuke.
dc.description.fil
Fil: Kamiya, Yuji.
dc.description.fil
Fil: Kusano, Miyako.
dc.description.fil
Fil: Saito, Kazuki.
dc.description.fil
Fil: Visa, Sofia.
dc.description.fil
Fil: Van Der Knaap, Esther.
dc.journal.title
Plant Physiology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.plantphysiol.org/content/168/3/1164.abstract
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741315/


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