Artículo
Context-specific functions of Notch in Drosophila blood cell progenitors
Blanco Obregón, Dalmiro Manuel
; Katz, Maximiliano Javier
; Durrieu, Lucía
; Gándara, Lautaro
; Wappner, Pablo
Fecha de publicación:
06/2020
Editorial:
Academic Press Inc Elsevier Science
Revista:
Developmental Biology
ISSN:
0012-1606
e-ISSN:
1095-564X
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Drosophila Larval hematopoiesis takes place at the lymph gland, where myeloid-like progenitors differentiate into Plasmatocytes and Crystal Cells, under regulation of conserved signaling pathways. It has been established that the Notch pathway plays a specific role in Crystal Cell differentiation and maintenance. In mammalian hematopoiesis, the Notch pathway has been proposed to fulfill broader functions, including Hematopoietic Stem Cell maintenance and cell fate decision in progenitors. In this work we describe different roles that Notch plays in the lymph gland. We show that Notch, activated by its ligand Serrate, expressed at the Posterior Signaling Center, is required to restrain Core Progenitor differentiation. We define a novel population of blood cell progenitors that we name Distal Progenitors, where Notch, activated by Serrate expressed in Lineage Specifying Cells at the Medullary Zone/Cortical Zone boundary, regulates a binary decision between Plasmatocyte and Crystal Cell fates. Thus, Notch plays context-specific functions in different blood cell progenitor populations of the Drosophila lymph gland.
Palabras clave:
HEMATOPOYESIS
,
DROSOPHILA
,
NOTCH
,
DIFFERENTIATION
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Identificadores
Colecciones
Articulos(IIBBA)
Articulos de INST.DE INVEST.BIOQUIMICAS DE BS.AS(I)
Articulos de INST.DE INVEST.BIOQUIMICAS DE BS.AS(I)
Citación
Blanco Obregón, Dalmiro Manuel; Katz, Maximiliano Javier; Durrieu, Lucía; Gándara, Lautaro; Wappner, Pablo; Context-specific functions of Notch in Drosophila blood cell progenitors; Academic Press Inc Elsevier Science; Developmental Biology; 462; 1; 6-2020; 101-115
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