Identifying causal relationships between EEG activity and intracranial pressure changes in neurocritical care patients

Abstract

Objective. To explore and assess the relationship between electroencephalography (EEG) activity and intracranial pressure (ICP) in patients suffering from traumatic brain injury (TBI) and subarachnoid hemorrhage (SAH) during their stay in an intensive care unit. Approach. We performed an observational prospective cohort study of adult patients suffering from TBI or SAH. Continuous EEG-ECG was performed during ICP monitoring. In every patient, variables derived from the EEG were calculated and the Granger causality (GC) methodology was employed to assess whether, and in which direction, there is any relationship betweenEEG and ICP. Main results. One-thousand fifty-five hours of continuous multimodal monitoring were analyzed in 21 patients using the GC test. During 37.88% of the analyzed time, significant GC statistic was found in the direction from the EEG activity to the ICP, with typical lags of 25?50 s between them. When recordings were adjusted by sedation?perfusion and/or bolus?and handling, these percentages hardly changed. Significance. Long-lasting, continuous and simultaneous EEG and ICP recordings from TBI and SAH patients provide highly rich and useful information, which has allowed for uncovering a strong relationshipbetween both signals. The use of this relationship could lead to developing a medical device tomeasure ICP in a non-invasive way.