Mostrar el registro sencillo del ítem
dc.contributor.author
Fendrik, Alejandro José
dc.contributor.author
Romanelli, Lilia Mabel
dc.contributor.author
Rotondo, Ernesto Federico
dc.date.available
2022-04-20T17:34:22Z
dc.date.issued
2018-03-01
dc.identifier.citation
Fendrik, Alejandro José; Romanelli, Lilia Mabel; Rotondo, Ernesto Federico; Neutral dynamics and cell renewal of colonic crypts in homeostatic regime; IOP Publishing; Physical Biology; 15; 3; 1-3-2018; 1-14
dc.identifier.issn
1478-3967
dc.identifier.uri
http://hdl.handle.net/11336/155460
dc.description.abstract
The self renewal process in colonic crypts is the object of several studies. We present here a new compartment model with the following characteristics: (a) we distinguish different classes of cells: stem cells, six generations of transit amplifying cells and the differentiated cells; (b) in order to take into account the monoclonal character of crypts in homeostatic regimes we include symmetric divisions of the stem cells. We first consider the dynamic differential equations that describe the evolution of the mean values of the populations, but the small observed value of the total number of cells involved plus the huge dispersion of experimental data found in the literature leads us to study the stochastic discrete process. This analysis allows us to study fluctuations, the neutral drift that leads to monoclonality, and the effects of the fixation of mutant clones.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
IOP Publishing
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/
dc.subject
COLONIC CRYPTS
dc.subject
NEUTRAL DRIFT
dc.subject
STEM CELLS
dc.subject
STOCHASTIC CELL RENEWAL
dc.subject
SYMMETRIC DIVISION
dc.subject.classification
Otras Ciencias Físicas
dc.subject.classification
Ciencias Físicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
Neutral dynamics and cell renewal of colonic crypts in homeostatic regime
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2022-04-20T14:49:12Z
dc.identifier.eissn
1478-3975
dc.journal.volume
15
dc.journal.number
3
dc.journal.pagination
1-14
dc.journal.pais
Reino Unido
dc.journal.ciudad
Londres
dc.description.fil
Fil: Fendrik, Alejandro José. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de General Sarmiento. Instituto de Ciencias; Argentina
dc.description.fil
Fil: Romanelli, Lilia Mabel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de General Sarmiento. Instituto de Ciencias; Argentina
dc.description.fil
Fil: Rotondo, Ernesto Federico. Universidad Nacional de General Sarmiento. Instituto de Ciencias; Argentina
dc.journal.title
Physical Biology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://stacks.iop.org/1478-3975/15/i=3/a=036003?key=crossref.06bf602b71f3c52a5fbf7884c80eab08
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1088/1478-3975/aaab9f
Archivos asociados