Artículo
Evolutionary coupling range varies widely among enzymes depending on selection pressure
Fecha de publicación:
19/10/2021
Editorial:
Cell Press
Revista:
Biophysical Journal
ISSN:
0006-3495
e-ISSN:
1542-0086
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Recent studies proposed that enzyme-active sites induce evolutionary constraints at long distances. The physical origin of such long-range evolutionary coupling is unknown. Here, I use a recent biophysical model of evolution to study the relationship between physical and evolutionary couplings on a diverse data set of monomeric enzymes. I show that evolutionary coupling is not universally long-range. Rather, range varies widely among enzymes, from 2 to 20 Å. Furthermore, the evolutionary coupling range of an enzyme does not inform on the underlying physical coupling, which is short range for all enzymes. Rather, evolutionary coupling range is determined by functional selection pressure.
Palabras clave:
Protein Evolution
,
Enzyme Evolution
,
Coupling
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Colecciones
Articulos (ICIFI)
Articulos de INSTITUTO DE CIENCIAS FISICAS
Articulos de INSTITUTO DE CIENCIAS FISICAS
Citación
Echave, Julian; Evolutionary coupling range varies widely among enzymes depending on selection pressure; Cell Press; Biophysical Journal; 120; 20; 19-10-2021; 4320-4324
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