Artículo
Nonclassical roles for IFN-γand IL-10 in a murine model of immunoedition
del Giúdice, Antonela
; Pagura, Lucas
; Capitani, María Celeste; Mainetti, Leandro Ernesto
; Scharovsky, Olga Graciela
; Di Masso, Ricardo Jose; Rico, Maria Jose
; Rozados, Viviana Rosa
Fecha de publicación:
12/2020
Editorial:
Future Science
Revista:
Future Science OA
e-ISSN:
2056-5623
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Aims: to characterize, by means of univariate and multivariate approaches, the Th1 and Th2 responses during the different phases of tumor immunoediting. Materials & Methods: we used a multivariate principal component analysis applied to analyze the joint behavior of serum concentrations of IFN-γ, IL-2, IL-10 and IL-4, during the different phases of tumor immunoediting, in CBi/L mice challenged with M-406 mammary adenocarcinoma. Results & Conclusions: Animals in equilibrium phase showed the widest variations in values of the four cytokines. In this experimental model the role of IFN-γ would be related to tumor growth and progression, while IL-10 would participate in the antitumor immune response. Lay abstract: Breast cancer is a complex, multifactor disease that affects about 10% of women in industrialized countries. The immune system has the ability to monitor the appearance of tumors, but the tumors have the ability to escape such rejection. For this reason, in order to design different therapeutic strategies, it is important to know the different mechanisms that take place when a tumor grows or when it is rejected. Here we sought to elucidate some of these mechanisms
Palabras clave:
IFN-γ
,
IL-10
,
IMMUNOEDITION
,
ANIMAL MODEL
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Articulos(CCT - ROSARIO)
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - ROSARIO
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - ROSARIO
Citación
del Giúdice, Antonela; Pagura, Lucas; Capitani, María Celeste; Mainetti, Leandro Ernesto; Scharovsky, Olga Graciela; et al.; Nonclassical roles for IFN-γand IL-10 in a murine model of immunoedition; Future Science; Future Science OA; 6; 10; 12-2020; 1-16
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