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Mazzini, Flavia Noelia
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Cook, Frank
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Gounarides, John
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Marciano, Sebastian
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Haddad, Leila
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Tamaroff, Ana Jesica
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Casciato, Paola
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Narvaez, Adriana Haydée
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Mascardi, María Florencia
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Anders, Margarita
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Orozco, Federico
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Quiroz, Nicolas
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Risk, Marcelo
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Gutt, Susana
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Gadano, Adrián Carlos
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Mendez Garcia, Celia
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Marro, Martin
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Penas Steinhardt, Alberto
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Trinks, Julieta
dc.date.available
2022-04-07T11:23:18Z
dc.date.issued
2020
dc.identifier.citation
Plasma and stool metabolomic biomarkers of non-alcoholic fatty liver disease in Argentina; The Liver Meeting Digital Experience; Estados Unidos; 2020; 1-4
dc.identifier.uri
http://hdl.handle.net/11336/154564
dc.description.abstract
Background: Non-invasive biomarkers are urgently needed to identify patients with non-alcoholic fatty liver disease (NAFLD) at risk of disease progression, particularly in high prevalence areas such as Latin America. In this regard, targeted metabolomics is a powerful technology for discovering new gut microbiome-derived metabolites. Thus, we aimed to identify potential metabolomic biomarkers related to NAFLD stage in Argentina, and to assess their relationship with clinical and host genetic factors. Methods: Adult healthy volunteers (HV) and biopsy-proven simple steatosis (SS) or non-alcoholic steatohepatitis (NASH) patients were recruited. Demographic, clinical and food frequency consumption data, as well as plasma and stool samples were collected. SNP rs738409 (PNPLA3 gene) was determined in all volunteers. HPLC and flow injection analysis with MS/MS in tandem was applied for metabolomic studies using the MxP Quant 500 Kit (Biocrates Life Sciences AG, Austria). Significantly different metabolites among groups were identified with MetaboAnalyst v4.0. Bivariate and multivariate analyses were used to identify variables that were independently related to NAFLD stage. Forward stepwise logistic regression models were constructed to design the best feature combination that could distinguish between study groups. Receiver Operating Characteristic (ROC) curves were used to evaluate models? accuracy.Results: 19 HV, 12 SS and 22 NASH patients were recruited. Diet was similar between groups. The concentration of 33 out of 424 detected metabolites (25 in plasma and 8 in stool) was significantly different among study groups. Levels of triglycerides (TG) were higher among NAFLD patients, whereas levels of phosphatidylcholines (PC) and lysoPC were higher among HV. The PNPLA3 risk genotype for NAFLD and NASH (GG) was related to higher plasma levels of eicosenoic acid FA(20:1) (p<0.001). Plasma metabolites showed a higher accuracy for diagnosis of NAFLD and NASH when compared to stool metabolites (Table 1). Body mass index (BMI) and plasma levels of PC aa C24:0, FA(20:1) and TG(16:1_34:1) showed high accuracy for diagnosis of NAFLD; whereas the best AUROC for discriminating NASH from SS was that of plasma levels of PC aa C24:0 and PC ae C40:1 (Table 1).Conclusions: Gut microbiome-derived metabolomic biomarkers were identified in plasma and stool, but plasma metabolites were better diagnostic biomarkers of NAFLD and NASH in Argentina. Further validation studies are needed.
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application/pdf
dc.language.iso
eng
dc.publisher
Wiley
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
MICROBIOME
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NAFLD
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METABOLITES
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ARGENTINA
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Bioquímica y Biología Molecular
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Plasma and stool metabolomic biomarkers of non-alcoholic fatty liver disease in Argentina
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info:eu-repo/semantics/publishedVersion
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info:eu-repo/semantics/conferenceObject
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info:ar-repo/semantics/documento de conferencia
dc.date.updated
2022-03-16T19:08:59Z
dc.journal.volume
72
dc.journal.pagination
1-4
dc.journal.pais
Estados Unidos
dc.description.fil
Fil: Mazzini, Flavia Noelia. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Medicina Traslacional E Ingenieria Biomedica. - Hospital Italiano. Instituto de Medicina Traslacional E Ingenieria Biomedica. - Instituto Universitario Hospital Italiano de Buenos Aires. Instituto de Medicina Traslacional E Ingenieria Biomedica.; Argentina
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Fil: Cook, Frank. Novartis Institutes For Biomedical Research; Estados Unidos
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Fil: Gounarides, John. Novartis Institutes For Biomedical Research; Estados Unidos
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Fil: Marciano, Sebastian. Hospital Italiano; Argentina
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Fil: Haddad, Leila. Hospital Italiano; Argentina
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Fil: Tamaroff, Ana Jesica. Hospital Italiano; Argentina
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Fil: Casciato, Paola. Hospital Italiano; Argentina
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Fil: Narvaez, Adriana Haydée. Hospital Italiano; Argentina
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Fil: Mascardi, María Florencia. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Medicina Traslacional E Ingenieria Biomedica. - Hospital Italiano. Instituto de Medicina Traslacional E Ingenieria Biomedica. - Instituto Universitario Hospital Italiano de Buenos Aires. Instituto de Medicina Traslacional E Ingenieria Biomedica.; Argentina
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Fil: Anders, Margarita. Hospital Alemán; Argentina
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Fil: Orozco, Federico. Hospital Alemán; Argentina
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Fil: Quiroz, Nicolas. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Medicina Traslacional E Ingenieria Biomedica. - Hospital Italiano. Instituto de Medicina Traslacional E Ingenieria Biomedica. - Instituto Universitario Hospital Italiano de Buenos Aires. Instituto de Medicina Traslacional E Ingenieria Biomedica.; Argentina
dc.description.fil
Fil: Risk, Marcelo. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Medicina Traslacional E Ingenieria Biomedica. - Hospital Italiano. Instituto de Medicina Traslacional E Ingenieria Biomedica. - Instituto Universitario Hospital Italiano de Buenos Aires. Instituto de Medicina Traslacional E Ingenieria Biomedica.; Argentina
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Fil: Gutt, Susana. Hospital Italiano; Argentina
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Fil: Gadano, Adrián Carlos. Hospital Italiano; Argentina
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Fil: Mendez Garcia, Celia. Hospital Italiano; Argentina
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Fil: Marro, Martin. Novartis Institutes For Biomedical Research; Estados Unidos
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Fil: Penas Steinhardt, Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni; Argentina
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Fil: Trinks, Julieta. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Medicina Traslacional e Ingeniería Biomédica - Hospital Italiano. Instituto de Medicina Traslacional e Ingeniería Biomédica.- Instituto Universitario Hospital Italiano de Buenos Aires. Instituto de Medicina Traslacional e Ingeniería Biomédica; Argentina
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://aasldpubs.onlinelibrary.wiley.com/doi/full/10.1002/hep.31579
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info:eu-repo/semantics/altIdentifier/url/https://engage.aasld.org/events/event-description?CalendarEventKey=2f9c87d2-1ad0-4ef1-b50e-0287a5f21342&Home=%2Fevents%2Fcalendar
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dc.coverage
Internacional
dc.type.subtype
Reunión
dc.description.nombreEvento
The Liver Meeting Digital Experience
dc.date.evento
2020-11-13
dc.description.paisEvento
Estados Unidos
dc.type.publicacion
Journal
dc.description.institucionOrganizadora
American Association for the Study of the Liver Disease
dc.source.revista
Hepatology
dc.date.eventoHasta
2020-11-16
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Reunión
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