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dc.contributor.author
Gutierrez, María de Los Angeles
dc.contributor.author
Palmieri, Mónica Alejandra
dc.contributor.author
Giuliani, Daniela Silvana
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Colman Lerner, Jorge Esteban
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Maglione, Guillermo Alberto
dc.contributor.author
Andrinolo, Dario
dc.contributor.author
Tasat, Deborah Ruth
dc.date.available
2022-04-04T19:00:14Z
dc.date.issued
2020-02-08
dc.identifier.citation
Gutierrez, María de Los Angeles; Palmieri, Mónica Alejandra; Giuliani, Daniela Silvana; Colman Lerner, Jorge Esteban; Maglione, Guillermo Alberto; et al.; Monitoring human genotoxicity risk associated to urban and industrial Buenos Aires air pollution exposure; Springer Heidelberg; Environmental Science and Pollution Research; 27; 08-2-2020; 13995-14006
dc.identifier.issn
0944-1344
dc.identifier.uri
http://hdl.handle.net/11336/154320
dc.description.abstract
The quality of life in large megacities is directly affected by its air quality. In urban environments, suspended particles from anthropogenic origin is one of the main air contaminants identified as highly genotoxic, mutagenic or carcinogenic. Atmospheric monitoring is therefore imperative and bioassays to detect the effects of genotoxic agents give usually excellent results. Analysis of micronucleus (MN) in exfoliated oral mucosa cells is a sensitive non-invasive method for monitoring genetic damage in human populations. The first aim of this study was to analyse and characterize levels of volatile organic compounds (VOCs), particulate matter (PM) and polycyclic aromatic hydrocarbons (PAHs) in two areas from Buenos Aires: La Plata city, an urban (U) area and Ensenada, an industrial (I) area. Secondly we evaluated the possible health risk of its inhabitants through a simple genotoxic assay on exfoliated oral mucosa cells. Whole blood cell count and nuclear abnormalities frequencies were evaluated in the exfoliated oral mucosa cells from urban and industrial inhabitants. Smoking habit represented a significant factor increasing MN percentage while age did not increased the production of any of the nuclear aberrations assayed (micronuclei, binucleated, karyorrhexis) when the inhabitants from the urban and the industrial areas were compared. In addition changes in MN and binucleated cell percentages in males and females, were found to be area-dependent. We suggest that regardless PM concentration, PM specific characteristics (size, shape, chemical elements, etc.) and VOCs levels could be responsible for the different harmful genotoxic effects seen in the two areas. Our results allowed to conclude that individuals living in both the urban and the industrial areas could be considered susceptible groups and should periodically undergo biological monitoring and appropriate care.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Springer Heidelberg
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
AIR POLLUTION
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URBAN ENVIRONMENT
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INDUSTRIAL ENVIRONMENT
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GENOTOXICITY
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MICRONUCLEUS
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Ciencias Medioambientales
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Ciencias de la Tierra y relacionadas con el Medio Ambiente
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CIENCIAS NATURALES Y EXACTAS
dc.title
Monitoring human genotoxicity risk associated to urban and industrial Buenos Aires air pollution exposure
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2021-04-23T19:07:05Z
dc.identifier.eissn
1614-7499
dc.journal.number
27
dc.journal.pagination
13995-14006
dc.journal.pais
Alemania
dc.journal.ciudad
Heidelberg
dc.description.fil
Fil: Gutierrez, María de Los Angeles. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Investigaciones del Medio Ambiente - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones del Medio Ambiente; Argentina
dc.description.fil
Fil: Palmieri, Mónica Alejandra. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Biodiversidad y Biología Experimental; Argentina
dc.description.fil
Fil: Giuliani, Daniela Silvana. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Investigaciones del Medio Ambiente - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones del Medio Ambiente; Argentina
dc.description.fil
Fil: Colman Lerner, Jorge Esteban. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigación y Desarrollo en Ciencias Aplicadas "Dr. Jorge J. Ronco". Universidad Nacional de la Plata. Facultad de Ciencias Exactas. Centro de Investigación y Desarrollo en Ciencias Aplicadas; Argentina
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Fil: Maglione, Guillermo Alberto. Universidad de Buenos Aires. Facultad de Odontología; Argentina
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Fil: Andrinolo, Dario. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Investigaciones del Medio Ambiente - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones del Medio Ambiente; Argentina
dc.description.fil
Fil: Tasat, Deborah Ruth. Universidad de Buenos Aires. Facultad de Odontología; Argentina. Universidad Nacional de San Martín. Escuela de Ciencia y Tecnología; Argentina
dc.journal.title
Environmental Science and Pollution Research
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1007/s11356-020-07863-9
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007/s11356-020-07863-9
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