Artículo
Dynamic neurocognitive changes in interoception after heart transplant
Salamone, Paula Celeste
; Sedeño, Lucas
; Legaz, Agustina
; Bekinschtein, Tristán Andrés
; Martorell Caro, Miguel Angel
; Gonzalez Adolfi, Federico
; Fraile Vazquez, Matías; Rodríguez Arriagada, Nicolás; Favaloro, Liliana Ethel; Peradejordi Lastras, Margarita Ana; Absi, Daniel O.; García, Adolfo Martín
; Favaloro, Roberto René; Ibañez, Agustin Mariano
Fecha de publicación:
07/2020
Editorial:
Oxford University Press
Revista:
Brain Communications
ISSN:
2632-1297
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Heart-brain integration dynamics are critical for interoception (i.e., the sensing of body-signals). In this unprecedented longitudinal study, we assessed neurocognitive markers of interoception in patients who underwent orthotopic heart transplants and matched healthy controls. Patients were assessed longitudinally before surgery (T1), a few months later (T2), and a year after (T3). We assessed behavioral (heartbeat detection) and electrophysiological (heartbeat evoked potential) markers of interoception. Heartbeat detection task revealed that pre-surgery (T1) interoception was similar between patients and controls. However, patients were outperformed by controls after heart transplant (T2), but no such differences were observed in the follow-up analysis (T3). Neurophysiologically, although heartbeat evoked potential analyses revealed no differences between groups before the surgery (T1), reduced amplitudes of this event-related potential were found for the patients in the two post-transplant stages (T2, T3). All these significant effects persisted after covariation with different cardiologic measures. In sum, this study brings new insights into the adaptive properties of brain-heart pathways.
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Articulos(INCYT)
Articulos de INSTITUTO DE NEUROCIENCIAS COGNITIVAS Y TRASLACIONAL
Articulos de INSTITUTO DE NEUROCIENCIAS COGNITIVAS Y TRASLACIONAL
Citación
Salamone, Paula Celeste; Sedeño, Lucas; Legaz, Agustina; Bekinschtein, Tristán Andrés; Martorell Caro, Miguel Angel; et al.; Dynamic neurocognitive changes in interoception after heart transplant; Oxford University Press; Brain Communications; 7-2020; 1-10
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