Artículo
Lactoferrin levels in cervical fluid from in vitro fertilization (IVF) patients: Correlation with IVF parameters
Massa, Estefanía María Alejandra
; Pelusa, Héctor Fabián; Lo Celso, Agustina Laura; Madariaga, Maria Jose; Filocco, Luciana Amanda; Morente, Carlos; Ghersevich, Sergio Albino
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Fecha de publicación:
05/2020
Editorial:
National Research Council Canada-NRC Research Press
Revista:
Biochemistry and Cell Biology
ISSN:
0829-8211
e-ISSN:
1208-6002
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Since our previous results suggest that lactoferrin (LF) might have roles in the reproductive process and that its levels might change in the female tract as a response to various factors, the aim of this investigation was to assess whether LF levels in cervical secretions correlate with reproductive parameters from in vitro fertilization (IVF) patients. Cervical fluid samples were obtained from 34 women under 40 years old enrolled for assisted reproduction techniques, and LF concentration was measured. The mean total protein concentration in all cervical fluid samples was 842.8 ± 116.9 µg/mL. The mean concentration of LF was 0.73 ± 0.06 ng LF/µg of total proteins. We observed that higher LF levels in cervical fluid correlated with lower IVF rates when all patients were analyzed; this negative correlation was also sustained when only patients ≥35 years were studied. The mean LF concentration in cervical fluid was significantly lower among patients with normal IVF rates than in those with values 50% or less. Using a LF cutoff value of 0.83 ng/μg of total proteins, the study revealed a significant association between the LF levels below 0.83 ng/µg of total proteins and IVF rates above 50%. LF levels in cervical mucus could potentially be used as a marker of fertilization outcome.
Palabras clave:
LACTOFERRIN
,
CERVICAL FLUID
,
IN VITRO FERTILIZATION
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos(CCT - ROSARIO)
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - ROSARIO
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - ROSARIO
Citación
Massa, Estefanía María Alejandra; Pelusa, Héctor Fabián; Lo Celso, Agustina Laura; Madariaga, Maria Jose; Filocco, Luciana Amanda; et al.; Lactoferrin levels in cervical fluid from in vitro fertilization (IVF) patients: Correlation with IVF parameters; National Research Council Canada-NRC Research Press; Biochemistry and Cell Biology; 99; 1; 5-2020; 1-27
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