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Artículo

Social Isolation in Male Rats During Adolescence Inhibits the Wnt/β-Catenin Pathway in the Prefrontal Cortex and Enhances Anxiety and Cocaine-Induced Plasticity in Adulthood

Cuesta, SantiagoIcon ; Funes, AlejandrinaIcon ; Pacchioni, Alejandra MariaIcon
Fecha de publicación: 06/2020
Editorial: Springer
Revista: Neuroscience Bulletin
ISSN: 1673-7067
e-ISSN: 1995-8218
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Drogadicción

Resumen

In adult animals, it is well established that stress has a proactive effect on psychostimulant responses. However, whether only a short period of stress during adolescence can also affect cocaine responses later in life and what mechanisms are involved are unknown. Here, we showed that 5 days of social isolation during rat adolescence had a long-term impact on anxiety-like behaviors, cocaine-induced conditioned place preference, and the expression of sensitization during adulthood. At the molecular level, social isolation decreased the activity of the Wnt/β-catenin pathway in the prefrontal cortex (PFC). Furthermore, after the expression of cocaine sensitization, isolated rats showed an increase in this pathway in the nucleus accumbens. Together, these findings suggest that, adolescent social isolation by altering the Wnt/β-catenin pathway in the developing PFC might increase the cocaine responses during adulthood, introducing this pathway as a novel neuroadaptation in the cortical-accumbens connection that may mediate a stress-induced increase in vulnerability to drugs.
Palabras clave: ADDICTION , STRESS , ADOLESCENCE , COCAINE
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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/154138
URL: http://link.springer.com/10.1007/s12264-020-00466-x
DOI: http://dx.doi.org/10.1007/s12264-020-00466-x
Colecciones
Articulos(CCT - ROSARIO)
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - ROSARIO
Citación
Cuesta, Santiago; Funes, Alejandrina; Pacchioni, Alejandra Maria; Social Isolation in Male Rats During Adolescence Inhibits the Wnt/β-Catenin Pathway in the Prefrontal Cortex and Enhances Anxiety and Cocaine-Induced Plasticity in Adulthood; Springer; Neuroscience Bulletin; 36; 6; 6-2020; 611-624
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