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dc.contributor.author
Ajayi, Ebenezer Idowu O
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dc.contributor.author
Fadiya, Oluwadamilola Victoria
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dc.contributor.author
Atanda, Joy Adeyemi
dc.contributor.author
Muhibi, Musa Abidemi
dc.contributor.author
Adeleke, M. A.
dc.date.available
2022-03-31T10:37:50Z
dc.date.issued
2019
dc.identifier.citation
Comparative seroepidemiological surveillance of visceral leishmaniasis and its association with diabetes co-morbidity in Osun State, Nigeria; 23rd European Congress of Clinical Chemistry and Laboratory Medicine; Barcelona; España; 2019; 1-2
dc.identifier.issn
0009-8981
dc.identifier.uri
http://hdl.handle.net/11336/154094
dc.description.abstract
Visceral leishmaniasis is the most severe form of leishmaniasis and the second largest parasitic killer in the world after malaria. This sero-epidemiology surveillance was carried out to ascertain visceral leishmaniasis incidence in Osun State, Southwestern Nigeria. Methods A total of 272 volunteers from different towns of the State were enrolled for participation in this study. They were grouped viz.: Control, Diabetic, Diabetic Foot Ulcer in order to investigate the incidence of VL and the association of the disease co-morbidity with diabetes viz-a-viz implication on biochemical parameters of kidney (Urea and Creatinine) and liver (ALT and AST) functions. Using standard protocols of ELISA, Buffy coat and thin film techniques, VL was diagnosed for each volunteer. Results Following screening, the Buffy coat (least recommended) technique did not detect the Leishmania parasite (0%), whereas the thin film examination (sensitivity: 2.3%, specificity: 99.6%, negative predictive value: 84.1%, positive predictive value: 50%) detected 2 (2.1%) while ELISA (the gold standard) detected 44 (16.2%) leishmaniasis cases among the participants. The results revealed statistically significant (p <0.05) decreased urea, increased creatinine, elevated ALT and AST levels in participants found to be infected with Leishmania species compared to those not infected. It is interesting to note that urea, creatinine, ALT and AST levels of participants having a co-morbidity of VL-diabetes and VL-diabetic foot ulcer did not change significantly compared to the Leishmania-infected participants without diabetes or the foot ulcer. Conclusions These findings indicate that Leishmania infection is the singular factor that perturbs the kidney and liver enzymes considered in this study. Therefore VL does not show association with diabetes or diabetic foot ulcer co-morbidity in the population studied. There has not been any reported case of visceral leishmaniasis in Osun State prior to this study. It therefore suffices that the infectious disease has hitherto remained un- or mis-diagnosed. Keywords: Visceral leishmanisis, diabetes, diabetic foot ulcer, kidney function, liver function.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier
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dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Visceral leishmanisis
dc.subject
Diabetic foot ulcer
dc.subject
Urea
dc.subject
Creatinine
dc.subject.classification
Otras Ciencias Químicas
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dc.subject.classification
Ciencias Químicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Comparative seroepidemiological surveillance of visceral leishmaniasis and its association with diabetes co-morbidity in Osun State, Nigeria
dc.type
info:eu-repo/semantics/publishedVersion
dc.type
info:eu-repo/semantics/conferenceObject
dc.type
info:ar-repo/semantics/documento de conferencia
dc.date.updated
2022-03-16T20:57:36Z
dc.journal.volume
493
dc.journal.pagination
1-2
dc.journal.pais
Bélgica
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dc.journal.ciudad
Gante
dc.description.fil
Fil: Ajayi, Ebenezer Idowu O. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
dc.description.fil
Fil: Fadiya, Oluwadamilola Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Biológicas y Tecnológicas. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Instituto de Investigaciones Biológicas y Tecnológicas; Argentina
dc.description.fil
Fil: Atanda, Joy Adeyemi. Osun State University; Nigeria
dc.description.fil
Fil: Muhibi, Musa Abidemi. Ladoke Akintola University of Technology Teaching Hospital; Nigeria
dc.description.fil
Fil: Adeleke, M. A.. Osun State University; Nigeria
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0009898119312276
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.cca.2019.03.1122
dc.conicet.rol
Autor
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dc.conicet.rol
Autor
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dc.conicet.rol
Autor
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dc.conicet.rol
Autor
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dc.coverage
Internacional
dc.type.subtype
Congreso
dc.description.nombreEvento
23rd European Congress of Clinical Chemistry and Laboratory Medicine
dc.date.evento
2019-05-19
dc.description.ciudadEvento
Barcelona
dc.description.paisEvento
España
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dc.type.publicacion
Journal
dc.description.institucionOrganizadora
International Federation of Clinical Chemistry and Laboratory Medicine
dc.description.institucionOrganizadora
European Federation of Laboratory Medicine
dc.description.institucionOrganizadora
Spanish Society of Laboratory Medicine
dc.source.revista
Clinica Chimica Acta
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dc.date.eventoHasta
2019-05-23
dc.type
Congreso
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