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dc.contributor.author
Khaligh, Fereshteh Ghahvechi
dc.contributor.author
Djadid, Navid Dinparast
dc.contributor.author
Farmani, Mostafa
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Asadi Saatlou, Zahra
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Frooziyan, Samira
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Abedi Astaneh, Fatemeh
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Farnoosh, Fariba
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Sofizadeh, Aioub
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Naseri, Firoozeh
dc.contributor.author
Adib, Delnia
dc.contributor.author
Taheri, Mohammad
dc.contributor.author
Lalehzari, Emran
dc.contributor.author
Pashaei, Shabnam
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Soltanbeiglou, Shadiyeh
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Soltani, Aboozar
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Khooban, Hassan
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Abbasi, Ebrahim
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Aivazi, Ali-Ashraf
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Saeedi, Samrand
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Taghilou, Behrooz
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Jafari, Abbas
dc.contributor.author
Dashti Khavidak, Kamal
dc.contributor.author
Toloza, Ariel Ceferino
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dc.contributor.author
Gholizadeh, Saber
dc.date.available
2022-03-25T15:57:19Z
dc.date.issued
2021-11
dc.identifier.citation
Khaligh, Fereshteh Ghahvechi; Djadid, Navid Dinparast; Farmani, Mostafa; Asadi Saatlou, Zahra; Frooziyan, Samira; et al.; Molecular monitoring of knockdown resistance in head louse (phthiraptera: Pediculidae) populations in iran; Entomological Society of America; Journal of Medical Entomology; 58; 6; 11-2021; 2321-2329
dc.identifier.issn
0022-2585
dc.identifier.uri
http://hdl.handle.net/11336/153904
dc.description.abstract
Knockdown resistance (kdr) is a common mechanism of insecticide resistance in head lice to the conventionally used pyrethroid pediculosis and can be the result of various amino acid substitutions within the voltage-sensitive sodium channel (VSSC). In this study, 54 sequences from varied specimens were investigated to monitor well-known resistance mutations and probable new mutations. The Pediculus humanus capitis de Geer specimens were collected from 13 provinces in Iran. The specimens were stored in 70% ethanol until DNA extraction and PCR amplification of ∼900-bp fragment of VSSC. The sequences were analyzed using different bioinformatics software for the detection of well-known kdr substitutions and additional mutations potentially associated with kdr resistance in head lice. There were six new and an old (haplotype I) kdr haplotypes within the Iranian head louse population. K794E, F815I, and N818D amino acid substitutions were reported for the first time. The P813H mutation was the most prevalent amino acid substitution in eight provinces. Among 53 sequences, 26 (49%) were homozygous susceptible, and 27 (51%) were heterozygotes. Thus, 51% of the head lice collected in Iran harbored only the P813H allele. The exact test for the Hardy-Weinberg (H-W) equilibrium showed that genotype frequencies differed significantly from the expectation in East-Azerbaijan and Tehran provinces. Moreover, these populations had an inbreeding coefficient (Fis) <0, indicating the excess of heterozygotes. This observation suggests that the populations of head lice from Iran are currently under active selective pressure. For the rest of the populations, H-W equilibrium and the expectations were significantly in harmony. The results of the current study highlight molecular techniques in the accurate detection of resistance genotypes before their establishment within the head louse population. Accurate detection of resistant genotypes seems to be helpful in decision-making on lice control programs and resistance monitoring and management.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Entomological Society of America
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
HEAD LOUSE
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KDR
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MOLECULAR RESISTANCE
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VSSC
dc.subject.classification
Zoología, Ornitología, Entomología, Etología
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dc.subject.classification
Ciencias Biológicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Molecular monitoring of knockdown resistance in head louse (phthiraptera: Pediculidae) populations in iran
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2022-03-08T21:19:35Z
dc.identifier.eissn
1938-2928
dc.journal.volume
58
dc.journal.number
6
dc.journal.pagination
2321-2329
dc.journal.pais
Estados Unidos
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dc.journal.ciudad
Lanham
dc.description.fil
Fil: Khaligh, Fereshteh Ghahvechi. Urmia University Of Medical Sciences; Irán
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Fil: Djadid, Navid Dinparast. Pasteur Institute Of Iran; Irán
dc.description.fil
Fil: Farmani, Mostafa. Urmia University Of Medical Sciences; Irán
dc.description.fil
Fil: Asadi Saatlou, Zahra. Urmia University Of Medical Sciences; Irán
dc.description.fil
Fil: Frooziyan, Samira. Urmia University Of Medical Sciences; Irán
dc.description.fil
Fil: Abedi Astaneh, Fatemeh. Qom University Of Medical Sciences And Health Services; Irán
dc.description.fil
Fil: Farnoosh, Fariba. Shahid Beheshti University Of Medical Sciences; Irán
dc.description.fil
Fil: Sofizadeh, Aioub. Golestan University Of Medical Sciences; Irán
dc.description.fil
Fil: Naseri, Firoozeh. No especifíca;
dc.description.fil
Fil: Adib, Delnia. Urmia University Of Medical Sciences; Irán
dc.description.fil
Fil: Taheri, Mohammad. Urmia University Of Medical Sciences; Irán
dc.description.fil
Fil: Lalehzari, Emran. Urmia University Of Medical Sciences; Irán
dc.description.fil
Fil: Pashaei, Shabnam. Urmia University Of Medical Sciences; Irán
dc.description.fil
Fil: Soltanbeiglou, Shadiyeh. Urmia University Of Medical Sciences; Irán
dc.description.fil
Fil: Soltani, Aboozar. No especifíca;
dc.description.fil
Fil: Khooban, Hassan. Qazvin University Of Medical Sciences; Irán
dc.description.fil
Fil: Abbasi, Ebrahim. Urmia University Of Medical Sciences; Irán
dc.description.fil
Fil: Aivazi, Ali-Ashraf. Ilam University Of Medical Sciences; Irán
dc.description.fil
Fil: Saeedi, Samrand. Kurdistan University Of Medical Sciences; Irán
dc.description.fil
Fil: Taghilou, Behrooz. No especifíca;
dc.description.fil
Fil: Jafari, Abbas. Urmia University Of Medical Sciences; Irán
dc.description.fil
Fil: Dashti Khavidak, Kamal. No especifíca;
dc.description.fil
Fil: Toloza, Ariel Ceferino. Consejo Nacional de Investigaciones Científicas y Técnicas. Unidad de Investigación y Desarrollo Estratégico para la Defensa. Ministerio de Defensa. Unidad de Investigación y Desarrollo Estratégico para la Defensa; Argentina
dc.description.fil
Fil: Gholizadeh, Saber. Urmia University Of Medical Sciences; Irán
dc.journal.title
Journal of Medical Entomology
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/jme/advance-article/doi/10.1093/jme/tjab101/6295458
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1093/jme/tjab101
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