Artículo
Attenuation of the Wnt/b-catenin/TCF pathway by in vivo interferon-a2b (IFN-a2b) treatment in preneoplastic rat livers
Parody, Juan Pablo
; Alvarez, Maria L.; Quiroga, Ariel Dario
; Frances, Daniel Eleazar Antonio
; Pisani, Gerardo B.; Carnovale, Cristina Ester
; Carrillo, Maria Cristina
Fecha de publicación:
2010
Editorial:
Taylor & Francis
Revista:
Growth Factors
ISSN:
0897-7194
e-ISSN:
1029-2292
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Wnt/β-catenin/T cell factor (TCF) pathway is activated in several types of human cancers, promoting cell growth and proliferation. Forkhead box containing protein class O (FOXO) transcription factors compete with TCF for β-catenin binding, particularly under cellular oxidative stress conditions. Contrary to β-catenin/TCF, β-catenin/FOXO promotes the transcription of genes involved in cell cycle arrest and apoptosis. We have previously demonstrated that in vivo interferon-α2b (IFN-α2b) administration induces apoptosis in preneoplastic livers, a mechanism mediated by reactive oxygen species (ROS) and transforming growth factor-β1 (TGF-β1). This study was aimed to assess the status of the Wnt/β-catenin/TCF pathway in a very early stage of rat hepatocarcinogenesis and to further evaluate the effects of in vivo IFN-α2b treatment on it. We demonstrated that the Wnt/β-catenin/TCF pathway is activated in preneoplastic rat livers. More important, in vivo IFN-α2b treatment inhibits Wnt/β-catenin/TCF pathway and promotes programed cell death possibly providing a link with FOXO pathway.
Palabras clave:
Hepatocarcinogenesis
,
Β-Catenin
,
Foxo
,
Oxidative Stress
,
Tcf
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Articulos(IFISE)
Articulos de INST.DE FISIOLOGIA EXPERIMENTAL (I)
Articulos de INST.DE FISIOLOGIA EXPERIMENTAL (I)
Citación
Parody, Juan Pablo; Alvarez, Maria L.; Quiroga, Ariel Dario; Frances, Daniel Eleazar Antonio; Pisani, Gerardo B.; et al.; Attenuation of the Wnt/b-catenin/TCF pathway by in vivo interferon-a2b (IFN-a2b) treatment in preneoplastic rat livers; Taylor & Francis; Growth Factors; 28; 3; -1-2010; 166-177
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