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dc.contributor.author
Drucaroff, Lucas Javier
dc.contributor.author
Fazzito, Maria Lucia
dc.contributor.author
Castro, Mariana Nair
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Nemeroff, Charles B.
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Guinjoan, Salvador Martín
dc.contributor.author
Villarreal, Mirta Fabiana
dc.date.available
2022-03-22T03:22:34Z
dc.date.issued
2020-11
dc.identifier.citation
Drucaroff, Lucas Javier; Fazzito, Maria Lucia; Castro, Mariana Nair; Nemeroff, Charles B.; Guinjoan, Salvador Martín; et al.; Insular functional alterations in emotional processing of schizophrenia patients revealed by Multivariate Pattern Analysis fMRI; Pergamon-Elsevier Science Ltd; Journal of Psychiatric Research; 130; 11-2020; 128-136
dc.identifier.issn
0022-3956
dc.identifier.uri
http://hdl.handle.net/11336/153687
dc.description.abstract
Emotion perception is impaired in schizophrenia patients (SP) and related to reduced social skills performance. There is a remarkable variability across subjects for functional neuroimaging alterations related to this phenomenon. In contrast to the univariate approaches of fMRI, Multivariate Pattern Analysis (MVPA) maintains the within-subject voxel-level variability. The purpose of this study was to assess emotion processing in SP, in previously identified ROIs -i.e. amygdala, hippocampus, insula, and thalamus-, while retaining the functional heterogeneity that may exist between subjects. We evaluated 23 SP and 23 healthy controls (HC). Happy, sad, and neutral faces were presented. A single trial fMRI model was applied. Patterns of activation within each ROI were classified at the subject level. Within each group, stimuli classification scores were tested against random label classification scores. In ROIs with significant results, a whole ROI classification was performed, to test whether en bloc stimuli discrimination was present. A between-group analysis was conducted also. For the classification of stimuli above chance, in the HC results were significant in the left insula in all of the stimuli dichotomies, but were non-significant in SP for happy vs. sad. In whole ROI classification, SP had significant results in bilateral insular cortex for happy vs. neutral. The left amygdala showed diminished stimuli classification scores in SP for sad vs. neutral. In conclusion, MVPA seems useful to study emotional processing in schizophrenia. In SP, either en bloc or no stimuli discrimination was seen in the insula, and reduced stimuli discrimination was seen in the left amygdala.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Pergamon-Elsevier Science Ltd
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
AMYGDALA
dc.subject
EMOTIONAL PROCESSING
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FMRI
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INSULA
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MULTIVARIATE PATTERN ANALYSIS (MVPA)
dc.subject
SCHIZOPHRENIA
dc.subject.classification
Otras Ciencias Médicas
dc.subject.classification
Otras Ciencias Médicas
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Insular functional alterations in emotional processing of schizophrenia patients revealed by Multivariate Pattern Analysis fMRI
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2022-03-14T21:08:43Z
dc.identifier.eissn
1879-1379
dc.journal.volume
130
dc.journal.pagination
128-136
dc.journal.pais
Estados Unidos
dc.description.fil
Fil: Drucaroff, Lucas Javier. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia. Instituto de Neurociencias - Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Neurociencias; Argentina
dc.description.fil
Fil: Fazzito, Maria Lucia. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia. Instituto de Neurociencias - Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Neurociencias; Argentina
dc.description.fil
Fil: Castro, Mariana Nair. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia. Instituto de Neurociencias - Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Neurociencias; Argentina
dc.description.fil
Fil: Nemeroff, Charles B.. University of Texas at Austin; Estados Unidos
dc.description.fil
Fil: Guinjoan, Salvador Martín. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia. Instituto de Neurociencias - Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Neurociencias; Argentina
dc.description.fil
Fil: Villarreal, Mirta Fabiana. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Física; Argentina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia. Instituto de Neurociencias - Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Neurociencias; Argentina
dc.journal.title
Journal of Psychiatric Research
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.jpsychires.2020.06.017
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0022395620308499
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