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dc.contributor.author
Butassi, Estefanía
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Svetaz, Laura Andrea
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Carpinella, Maria Cecilia
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Efferth, Thomas
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Zacchino, Susana Alicia Stella
dc.date.available
2022-03-18T03:49:10Z
dc.date.issued
2021-09
dc.identifier.citation
Butassi, Estefanía; Svetaz, Laura Andrea; Carpinella, Maria Cecilia; Efferth, Thomas; Zacchino, Susana Alicia Stella; Fungal biofilms as a valuable target for the discovery of natural products that cope with the resistance of medically important fungi—Latest findings; Multidisciplinary Digital Publishing Institute; Antibiotics; 10; 9; 9-2021; 1-31
dc.identifier.issn
2079-6382
dc.identifier.uri
http://hdl.handle.net/11336/153564
dc.description.abstract
The development of new antifungal agents that target biofilms is an urgent need. Natural products, mainly from the plant kingdom, represent an invaluable source of these entities. The present review provides an update (2017–May 2021) on the available information on essential oils, propolis, extracts from plants, algae, lichens and microorganisms, compounds from different natural sources and nanosystems containing natural products with the capacity to in vitro or in vivo modulate fungal biofilms. The search yielded 42 articles; seven involved essential oils, two Brazilian propolis, six plant extracts and one of each, extracts from lichens and algae/cyanobacteria. Twenty articles deal with the antibiofilm effect of pure natural compounds, with 10 of them including studies of the mechanism of action and five dealing with natural compounds included in nanosystems. Thirty‐seven manuscripts evaluated Candida spp. biofilms and two tested Fusarium and Cryptococcus spp. Only one manuscript involved Aspergillus fumigatus. From the data presented here, it is clear that the search of natural products with activity against fungal biofilms has been a highly active area of research in recent years. However, it also reveals the necessity of deepening the studies by (i) evaluating the effect of natural products on biofilms formed by the newly emerged and worrisome health‐care associated fungi, C. auris, as well as on other non‐albicans Candida spp., Cryptococcus sp. and filamentous fungi; (ii) elucidating the mechanisms of action of the most active natural products; (iii) increasing the in vivo testing.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Multidisciplinary Digital Publishing Institute
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/
dc.subject
ANTIFUNGAL RESISTANCE
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CANDIDA SPP
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CRYPTOCOCCUS SPP
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FILAMENTOUS FUNGI
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FUNGAL BIOFILM
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FUSARIUM SPP
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MECHANISMS OF ANTIBIOFILM ACTION
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NATURAL PRODUCTS
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Química Orgánica
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Ciencias Químicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Fungal biofilms as a valuable target for the discovery of natural products that cope with the resistance of medically important fungi—Latest findings
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2022-03-09T18:02:32Z
dc.identifier.eissn
2079-6382
dc.journal.volume
10
dc.journal.number
9
dc.journal.pagination
1-31
dc.journal.pais
Suiza
dc.journal.ciudad
Basilea
dc.description.fil
Fil: Butassi, Estefanía. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Química Orgánica. Área Farmacognosia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina
dc.description.fil
Fil: Svetaz, Laura Andrea. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Química Orgánica. Área Farmacognosia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina
dc.description.fil
Fil: Carpinella, Maria Cecilia. Universidad Católica de Córdoba. Instituto de Investigaciones en Recursos Naturales y Sustentabilidad José Sanchez Labrador S. J. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Recursos Naturales y Sustentabilidad José Sanchez Labrador S. J.; Argentina
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Fil: Efferth, Thomas. Johannes Gutenberg Universitat Mainz; Alemania
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Fil: Zacchino, Susana Alicia Stella. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Química Orgánica. Área Farmacognosia; Argentina
dc.journal.title
Antibiotics
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2079-6382/10/9/1053
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3390/antibiotics10091053
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