Artículo
A New Series of Antibacterial Nitrosopyrimidines: Synthesis and 3 Structure?Activity Relationship
Olivella, Monica; Marchal, Antonio; Nogueras, Manuel; Melguizo, Manuel; Lima, Beatriz Viviana
; Tapia, Alejandro; Feresin, Gabriela Egly
; Parravicini, Oscar
; Giannini, Fernando; Andujar, Sebastian Antonio
; Cobo, Justo; Enriz, Ricardo Daniel
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Fecha de publicación:
01/2015
Editorial:
Wiley
Revista:
Archiv der Pharmazie - Chemistry in Life Sciences
ISSN:
1521-4184
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
New nitrosopyrimidines were synthesized and evaluated as potential antibacterial agents. Different compounds structurally related with 4,6-bis(alkyl or arylamino)-5-nitrosopyrimidines were evaluated. Some of these nitrosopyrimidines displayed significant antibacterial activity against human pathogenic bacteria. Among them compounds 1c, 2a–c, and 9a–c exhibited remarkable activity against methicillin-sensitive and -resistant Staphylococcus aureus, Escherichia coli, Yersinia enterocolitica, and Salmonella enteritidis. A detailed structure–activity relationship study, supported by theoretical calculations, aided us to identify and understand the minimal structural requirements for the antibacterial action of the nitrosopyrimidines reported here. Thus, our results have led us to identify a topographical template that provides a guide for the design of new nitrosopyrimidines with antibacterial effects.
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Articulos(CCT - NOA SUR)
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - NOA SUR
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - NOA SUR
Articulos(IMIBIO-SL)
Articulos de INST. MULTIDICIPLINARIO DE INV. BIO. DE SAN LUIS
Articulos de INST. MULTIDICIPLINARIO DE INV. BIO. DE SAN LUIS
Articulos(SEDE CENTRAL)
Articulos de SEDE CENTRAL
Articulos de SEDE CENTRAL
Citación
Olivella, Monica; Marchal, Antonio; Nogueras, Manuel; Melguizo, Manuel; Lima, Beatriz Viviana; et al.; A New Series of Antibacterial Nitrosopyrimidines: Synthesis and 3 Structure?Activity Relationship; Wiley; Archiv der Pharmazie - Chemistry in Life Sciences; 348; 1; 1-2015; 68-80
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