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dc.contributor.author
Babola, Travis A.  
dc.contributor.author
Li, Sally  
dc.contributor.author
Wang, Zhirong  
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Kersbergen, Calvin J.  
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Elgoyhen, Ana Belen  
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Coate, Thomas M.  
dc.contributor.author
Bergles, Dwight E.  
dc.date.available
2022-03-11T02:05:03Z  
dc.date.issued
2021-01  
dc.identifier.citation
Babola, Travis A.; Li, Sally; Wang, Zhirong; Kersbergen, Calvin J.; Elgoyhen, Ana Belen; et al.; Purinergic Signaling Controls Spontaneous Activity in the Auditory System throughout Early Development; Society for Neuroscience; Journal of Neuroscience; 41; 4; 1-2021; 594-612  
dc.identifier.issn
0270-6474  
dc.identifier.uri
http://hdl.handle.net/11336/153196  
dc.description.abstract
Spontaneous bursts of electrical activity in the developing auditory system arise within the cochlea before hearing onset and propagate through future sound-processing circuits of the brain to promote maturation of auditory neurons. Studies in isolated cochleae revealed that this intrinsically generated activity is initiated by ATP release from inner supporting cells (ISCs), resulting in activation of purinergic autoreceptors, K+ efflux, and subsequent depolarization of inner hair cells. However, it is unknown when this activity emerges or whether different mechanisms induce activity during distinct stages of development. Here we show that spontaneous electrical activity in mouse cochlea from both sexes emerges within ISCs during the late embryonic period, preceding the onset of spontaneous correlated activity in inner hair cells and spiral ganglion neurons, which begins at birth and follows a base to apex developmental gradient. At all developmental ages, pharmacological inhibition of P2Y1 purinergic receptors dramatically reduced spontaneous activity in these three cell types. Moreover, in vivo imaging within the inferior colliculus revealed that auditory neurons within future isofrequency zones exhibit coordinated neural activity at birth. The frequency of these discrete bursts increased progressively during the postnatal prehearing period yet remained dependent on P2RY1. Analysis of mice with disrupted cholinergic signaling in the cochlea indicate that this efferent input modulates, rather than initiates, spontaneous activity before hearing onset. Thus, the auditory system uses a consistent mechanism involving ATP release from ISCs and activation of P2RY1 autoreceptors to elicit coordinated excitation of neurons that will process similar frequencies of sound.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Society for Neuroscience  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
A9  
dc.subject
COCHLEA  
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INFERIOR COLLICULUS  
dc.subject
P2RY1  
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POTASSIUM BUFFERING  
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PURINERGIC  
dc.subject.classification
Neurociencias  
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Medicina Básica  
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CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
Purinergic Signaling Controls Spontaneous Activity in the Auditory System throughout Early Development  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2021-12-13T18:57:43Z  
dc.journal.volume
41  
dc.journal.number
4  
dc.journal.pagination
594-612  
dc.journal.pais
Estados Unidos  
dc.journal.ciudad
Washington  
dc.description.fil
Fil: Babola, Travis A.. University Johns Hopkins; Estados Unidos  
dc.description.fil
Fil: Li, Sally. University Johns Hopkins; Estados Unidos  
dc.description.fil
Fil: Wang, Zhirong. University Of Georgetown; Estados Unidos  
dc.description.fil
Fil: Kersbergen, Calvin J.. University Johns Hopkins; Estados Unidos  
dc.description.fil
Fil: Elgoyhen, Ana Belen. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina  
dc.description.fil
Fil: Coate, Thomas M.. University Johns Hopkins; Estados Unidos  
dc.description.fil
Fil: Bergles, Dwight E.. University Johns Hopkins; Estados Unidos  
dc.journal.title
Journal of Neuroscience  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.jneurosci.org/lookup/doi/10.1523/JNEUROSCI.2178-20.2020  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1523/JNEUROSCI.2178-20.2020