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dc.contributor.author
Babola, Travis A.
dc.contributor.author
Li, Sally
dc.contributor.author
Wang, Zhirong
dc.contributor.author
Kersbergen, Calvin J.
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Elgoyhen, Ana Belen
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Coate, Thomas M.
dc.contributor.author
Bergles, Dwight E.
dc.date.available
2022-03-11T02:05:03Z
dc.date.issued
2021-01
dc.identifier.citation
Babola, Travis A.; Li, Sally; Wang, Zhirong; Kersbergen, Calvin J.; Elgoyhen, Ana Belen; et al.; Purinergic Signaling Controls Spontaneous Activity in the Auditory System throughout Early Development; Society for Neuroscience; Journal of Neuroscience; 41; 4; 1-2021; 594-612
dc.identifier.issn
0270-6474
dc.identifier.uri
http://hdl.handle.net/11336/153196
dc.description.abstract
Spontaneous bursts of electrical activity in the developing auditory system arise within the cochlea before hearing onset and propagate through future sound-processing circuits of the brain to promote maturation of auditory neurons. Studies in isolated cochleae revealed that this intrinsically generated activity is initiated by ATP release from inner supporting cells (ISCs), resulting in activation of purinergic autoreceptors, K+ efflux, and subsequent depolarization of inner hair cells. However, it is unknown when this activity emerges or whether different mechanisms induce activity during distinct stages of development. Here we show that spontaneous electrical activity in mouse cochlea from both sexes emerges within ISCs during the late embryonic period, preceding the onset of spontaneous correlated activity in inner hair cells and spiral ganglion neurons, which begins at birth and follows a base to apex developmental gradient. At all developmental ages, pharmacological inhibition of P2Y1 purinergic receptors dramatically reduced spontaneous activity in these three cell types. Moreover, in vivo imaging within the inferior colliculus revealed that auditory neurons within future isofrequency zones exhibit coordinated neural activity at birth. The frequency of these discrete bursts increased progressively during the postnatal prehearing period yet remained dependent on P2RY1. Analysis of mice with disrupted cholinergic signaling in the cochlea indicate that this efferent input modulates, rather than initiates, spontaneous activity before hearing onset. Thus, the auditory system uses a consistent mechanism involving ATP release from ISCs and activation of P2RY1 autoreceptors to elicit coordinated excitation of neurons that will process similar frequencies of sound.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Society for Neuroscience
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
A9
dc.subject
COCHLEA
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INFERIOR COLLICULUS
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P2RY1
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POTASSIUM BUFFERING
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PURINERGIC
dc.subject.classification
Neurociencias
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Purinergic Signaling Controls Spontaneous Activity in the Auditory System throughout Early Development
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2021-12-13T18:57:43Z
dc.journal.volume
41
dc.journal.number
4
dc.journal.pagination
594-612
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Washington
dc.description.fil
Fil: Babola, Travis A.. University Johns Hopkins; Estados Unidos
dc.description.fil
Fil: Li, Sally. University Johns Hopkins; Estados Unidos
dc.description.fil
Fil: Wang, Zhirong. University Of Georgetown; Estados Unidos
dc.description.fil
Fil: Kersbergen, Calvin J.. University Johns Hopkins; Estados Unidos
dc.description.fil
Fil: Elgoyhen, Ana Belen. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina
dc.description.fil
Fil: Coate, Thomas M.. University Johns Hopkins; Estados Unidos
dc.description.fil
Fil: Bergles, Dwight E.. University Johns Hopkins; Estados Unidos
dc.journal.title
Journal of Neuroscience
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.jneurosci.org/lookup/doi/10.1523/JNEUROSCI.2178-20.2020
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1523/JNEUROSCI.2178-20.2020
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