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dc.contributor.author
Garces, María Fernanda
dc.contributor.author
Rodriguez Navarro, Haiver Antonio
dc.contributor.author
Buell Acosta, Julieth Daniela
dc.contributor.author
Burgos Cardenas, Alvaro Javier
dc.contributor.author
Franco Vega, Roberto
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Maldonado Acosta, Luis Miguel
dc.contributor.author
Eslava Schmalbach, Javier
dc.contributor.author
Parada Baños, Arturo José
dc.contributor.author
Castro Pinzon, Andres
dc.contributor.author
Sanchez, Elizabeth
dc.contributor.author
Angel Muller, Edith
dc.contributor.author
Lacunza, Ezequiel
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dc.contributor.author
Castaño, Justo P.
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Dieguez, Carlos
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Nogueiras, Rubén
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Ruiz Parra, Ariel Ivan
dc.contributor.author
Caminos, Jorge Eduardo
dc.date.available
2022-03-04T02:20:30Z
dc.date.issued
2021-04
dc.identifier.citation
Garces, María Fernanda; Rodriguez Navarro, Haiver Antonio; Buell Acosta, Julieth Daniela; Burgos Cardenas, Alvaro Javier; Franco Vega, Roberto; et al.; Maternal serum angiopoietin-like 3 levels in healthy and mild preeclamptic pregnant women; Frontiers Media S.A.; Frontiers in Endocrinology; 12; 670357; 4-2021; 1-8
dc.identifier.uri
http://hdl.handle.net/11336/152888
dc.description.abstract
Objective: Angiopoietin-like protein 3(ANGPTL3) is an important regulator of lipoprotein metabolism in the fed state by inhibiting the enzyme lipoprotein lipase in oxidative tissues. However, the possible role of ANGPTL3 throughout gestation and its relationship with hormonal and biochemical variables are still unknown. The aim of this study was to determinate serum ANGPTL3 level in healthy non-pregnant women, during healthy and preeclamptic pregnancy and postpartum. Methods: Serum ANGPTL3 was analyzed by enzyme-linked immunosorbent assay (ELISA), in a prospective cohort of healthy pregnant women (n = 52) and women with mild preeclampsia (n = 21), and women at three months postpartum (n = 20) and healthy non-pregnant women (n = 20). The results obtained were correlated with biochemical, hormonal and anthropometric variables and insulin resistance indices. Results: Levels of ANGPTL3 were not different between the follicular and the luteal phases of the cycle in healthy non-pregnant women. There was a significant reduction in serum ANGPTL3 levels from the first to the third trimester in healthy pregnant women compared with healthy non-pregnant and postpartum women (p <0.01). ANGPTL3 levels do not differ significantly during the three trimesters of pregnancy neither in healthy women nor in preeclamptic women. The serum levels of ANGPTL3 in women who developed preeclampsia are not statistically different from those observed in healthy pregnant women in each trimester of pregnancy. A significant lineal positive correlation was observed between serum ANGPTL3 levels and triglyceride (P =0.0186, r =0.52), very low-density lipoprotein cholesterol (P =0.0224, r =0.50), and total cholesterol levels (P =0.0220, r =0.50) in healthy non-pregnant women (P 0.05). Besides, there were no significant correlations between serum ANGPTL3 and body mass index (BMI), high-density lipoprotein cholesterol, glucose, insulin, leptin, or HOMA-IR (P >0.05) Conclusions: We describe for the first time the profile of ANGPTL3 throughout pregnancy and postpartum as well as and discussed about explore their potential contribution interactions with lipoprotein metabolism throughout pregnancy and postpartum. Thus, low levels of ANGPTL3 during pregnancy might favor lipid uptake in oxidative tissues as the main maternal energy source, while may helping to preserve glucose for use by the fetus and placenta.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Frontiers Media S.A.
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
ANGPTL
dc.subject
ANGPTL3
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INSULIN RESISTANCE
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PREECLAMPSIA
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PREGNANCY
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Bioquímica y Biología Molecular
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Ciencias Biológicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Maternal serum angiopoietin-like 3 levels in healthy and mild preeclamptic pregnant women
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2022-03-02T15:46:48Z
dc.identifier.eissn
1664-2392
dc.journal.volume
12
dc.journal.number
670357
dc.journal.pagination
1-8
dc.journal.pais
Suiza
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dc.description.fil
Fil: Garces, María Fernanda. Universidad Nacional de Colombia; Colombia
dc.description.fil
Fil: Rodriguez Navarro, Haiver Antonio. Universidad Nacional de Colombia; Colombia
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Fil: Buell Acosta, Julieth Daniela. Universidad Nacional de Colombia; Colombia
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Fil: Burgos Cardenas, Alvaro Javier. Universidad Nacional de Colombia; Colombia
dc.description.fil
Fil: Franco Vega, Roberto. Universidad Nacional de Colombia; Colombia
dc.description.fil
Fil: Maldonado Acosta, Luis Miguel. Universidad Nacional de Colombia; Colombia
dc.description.fil
Fil: Eslava Schmalbach, Javier. Universidad Nacional de Colombia; Colombia
dc.description.fil
Fil: Parada Baños, Arturo José. Universidad Nacional de Colombia; Colombia
dc.description.fil
Fil: Castro Pinzon, Andres. Universidad Nacional de Colombia; Colombia
dc.description.fil
Fil: Sanchez, Elizabeth. Universidad Nacional de Colombia; Colombia
dc.description.fil
Fil: Angel Muller, Edith. Universidad Nacional de Colombia; Colombia
dc.description.fil
Fil: Lacunza, Ezequiel. Universidad Nacional de La Plata. Facultad de Ciencias Médicas. Centro de Investigaciones Inmunológicas Básicas y Aplicadas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
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Fil: Castaño, Justo P.. Universidad de Córdoba; España
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Fil: Dieguez, Carlos. Universidad de Santiago de Compostela; España
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Fil: Nogueiras, Rubén. Universidad de Santiago de Compostela; España
dc.description.fil
Fil: Ruiz Parra, Ariel Ivan. Universidad Nacional de Colombia; Colombia
dc.description.fil
Fil: Caminos, Jorge Eduardo. Universidad Nacional de Colombia; Colombia
dc.journal.title
Frontiers in Endocrinology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3389/fendo.2021.670357
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fendo.2021.670357/full
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