A Class 2 Integron with a Novel Cassette Array in a Burkholderia cenocepacia Isolate

Abstract

Burkholderia cepacia complex (BCC) are gram-negative opportunistic emerging pathogens associated with a poor prognosis for patients with cystic fibrosis (CF). Carbapenems and ceftazidime are administrated to patients suffering from BCC infections, and trimethoprim-sulfamethoxazole has historically been the drug of choice. Recently, the acquisition of determinants to sulfamethoxazole located in the 3´-conserved region of class 1 integrons have been described in BCC isolates from CF patients. The goal of this study was to determine the presence of class 1, 2 and 3 integrons in a Burkholderia cenocepacia (BC1) strain that was isolated from the sputum of a 14-years-old CF patient in a surgery and transplant center from Buenos Aires City, Argentina.