Artículo
Intrahepatic immune infiltrate in chronic hepatitis B and chronic hepatitis C: Similar but not the same
Giadans, Cecilia Graciela
; Rios, Daniela Alejandra
; Ameigeiras, Beatriz; Haddad, Leila; de Matteo, Elena Noemí
; Valva, Pamela
; Preciado, María Victoria
Fecha de publicación:
11/2021
Editorial:
Wiley Blackwell Publishing, Inc
Revista:
Journal Of Viral Hepatitis.
ISSN:
1352-0504
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
In chronic hepatitis B (CHB) and C (CHC) infections, the composition of the immune cell microenvironment at the site of infection is poorly understood. Thus, our aim was to characterize and compare liver infiltrates to identify shared and exclusive hepatic immune components. Immunohistochemistry was performed on 26 CHB and 42 CHC liver biopsies to determine Th (CD4+), Th1 (T-bet+), Th17 (IL-17A+), Treg (Foxp3+) and CTL (CD8+) cells frequency in portal/periportal and intralobular areas and relate them to liver damage. CHB and CHC cases shared a portal/periportal CD4+ lymphocyte predominance and a lobular CD8+ lymphocyte majority. However, CHC exhibited a concomitant lobular T-bet+ cell dominance while in CHB FoxP3+ cells prevail. CHC disclosed higher frequencies of P/P FoxP3+, IL-17A+ and T-bet+ cells and intralobular CD4+, IL-17A+ and T-bet+ lymphocytes. HBeAg+ chronic hepatitis and CHC cell frequencies were similar except for lobular T-bet+ that remained higher among CHC cases. Comparison among cases with less severe liver disease revealed lower lymphocyte frequencies in CHB samples, while no differences were observed between patients with more severe stages. Interestingly, in CHB portal/periportal CD4+ and lobular CD4+, CD8+ and IL-17A+ cells were associated with severe hepatitis. Even when all studied populations were identified in both infections preferential lymphocyte frequencies and prevalence at different areas along with their association with liver damage highlighted that CHB and CHC immune responses are not the same.
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Articulos(IMIPP)
Articulos de INSTITUTO MULTIDISCIPLINARIO DE INVESTIGACIONES EN PATOLOGIAS PEDIATRICAS
Articulos de INSTITUTO MULTIDISCIPLINARIO DE INVESTIGACIONES EN PATOLOGIAS PEDIATRICAS
Citación
Giadans, Cecilia Graciela; Rios, Daniela Alejandra; Ameigeiras, Beatriz; Haddad, Leila; de Matteo, Elena Noemí; et al.; Intrahepatic immune infiltrate in chronic hepatitis B and chronic hepatitis C: Similar but not the same; Wiley Blackwell Publishing, Inc; Journal Of Viral Hepatitis.; 29; 2; 11-2021; 124-134
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