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dc.contributor.author
Martín Giménez, Virna Margarita
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dc.contributor.author
Bergam, Ivana
dc.contributor.author
Reiter, Russel
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dc.contributor.author
Manucha, Walter Ariel Fernando
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dc.date.available
2022-02-24T12:52:44Z
dc.date.issued
2021-09
dc.identifier.citation
Martín Giménez, Virna Margarita; Bergam, Ivana; Reiter, Russel; Manucha, Walter Ariel Fernando; Metal ion homeostasis with emphasis on zinc and copper: Potential crucial link to explain the non-classical antioxidative properties of vitamin D and melatonin; Pergamon-Elsevier Science Ltd; Life Sciences; 281; 9-2021; 1-5
dc.identifier.issn
0024-3205
dc.identifier.uri
http://hdl.handle.net/11336/152652
dc.description.abstract
Metal ion homeostasis is an essential physiological mechanism necessary for achieving an adequate balance of these ions´ concentrations in the different cellular compartments. This fact is of great importance because both an excess and a deficiency of cellular metal ion levels are usually equally harmful due to the exacerbated increase in oxidative stress that may occur in both cases. Metal ion homeostasis ensures an equilibrium among multiple functions associated with the body´s antioxidative defense network controlled by metallic micronutrients such as zinc and copper, some of the central regulators of redox processes. These micronutrients significantly modulate the activity of some isoforms of superoxide dismutase (SOD) and other enzymes such as metallothioneins (MTs) and ceruloplasmin (CP), which are directly or indirectly involved in the regulation of redox homeostasis. Although it is well known that both melatonin (MEL) and vitamin D have important roles as natural antioxidants, often some of these effects are related to their actions on antioxidative processes dependent on metal ions. Thus, in addition to their classical antioxidative properties usually associated with mitochondrial effects, it is known that MEL and vitamin D modulate the expression and activity of Cu/Zn-dependent SOD isoforms, MTs and CP; function as copper chelators and regulate genomic and non-genomic mechanisms related to the zinc transport. This review summarizes the main findings related to the crucial participation of zinc and copper in physiological antioxidative status and their relationship with the non-classical antioxidant effects of MEL and vitamin D, suggesting a potential synergism among these four micronutrients.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Pergamon-Elsevier Science Ltd
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dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
ANTIOXIDANT
dc.subject
COPPER
dc.subject
MELATONIN
dc.subject
OXIDATIVE STRESS
dc.subject
VITAMIN D
dc.subject
ZINC
dc.subject.classification
Nutrición, Dietética
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dc.subject.classification
Ciencias de la Salud
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Metal ion homeostasis with emphasis on zinc and copper: Potential crucial link to explain the non-classical antioxidative properties of vitamin D and melatonin
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2022-02-22T16:50:00Z
dc.journal.volume
281
dc.journal.pagination
1-5
dc.journal.pais
Estados Unidos
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dc.description.fil
Fil: Martín Giménez, Virna Margarita. Universidad Católica de Cuyo. Facultad de Ciencias Químicas y Tecnológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Bergam, Ivana. No especifíca;
dc.description.fil
Fil: Reiter, Russel. No especifíca;
dc.description.fil
Fil: Manucha, Walter Ariel Fernando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
dc.journal.title
Life Sciences
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0024320521007566
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.lfs.2021.119770
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