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dc.contributor.author
Chiesa, Juan José
dc.contributor.author
Duhart, José Manuel
dc.contributor.author
Casiraghi, Leandro Pablo
dc.contributor.author
Paladino, Natalia
dc.contributor.author
Bussi, Ivana Leda
dc.contributor.author
Golombek, Diego Andrés
dc.contributor.other
Aguilar Roblero, Raúl
dc.contributor.other
Díaz Muñoz, Mauricio
dc.contributor.other
Fanjul Moles, Mária Luisa
dc.date.available
2022-02-23T14:21:12Z
dc.date.issued
2015
dc.identifier.citation
Chiesa, Juan José; Duhart, José Manuel; Casiraghi, Leandro Pablo; Paladino, Natalia; Bussi, Ivana Leda; et al.; Effects of circadian disruption on physiology and pathology: from bench to clinic (and back); Springer; 2015; 289-320
dc.identifier.isbn
978-3-319-08944-7
dc.identifier.uri
http://hdl.handle.net/11336/152592
dc.description.abstract
Nested within the hypothalamus, the suprachiasmatic nuclei (SCN) represent a central biological clock that regulates daily and circadian (i.e., close to 24 h) rhythms in mammals. Besides the SCN, a number of peripheral oscillators throughout the body control local rhythms and are usually kept in pace by the central clock. In order to represent an adaptive value, circadian rhythms must be entrained by environmental signals or zeitgebers, the main one being the daily light?dark (LD) cycle. The SCN adopt a stable phase relationship with the LD cycle that, when challenged, results in abrupt or chronic changes in overt rhythms and, in turn, in physiological, behavioral, and metabolic variables. Changes in entrainment, both acute and chronic, may have severe consequences in human performance and pathological outcome. Indeed, animal models of desynchronization have become a useful tool to understand such changes and to evaluate potential treatments in human subjects. Here we review a number of alterations in circadian entrainment, including jet lag, social jet lag (i.e., desynchronization between body rhythms and normal time schedules), shift work, and exposure to nocturnal light, both in human subjects and in laboratory animals. Finally, we focus on the health consequences related to circadian/entrainment disorders and propose a number of approaches for the management of circadian desynchronization.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Springer
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
circadian disruption
dc.subject
jet lag
dc.subject
shift work
dc.subject.classification
Biología
dc.subject.classification
Ciencias Biológicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
Effects of circadian disruption on physiology and pathology: from bench to clinic (and back)
dc.type
info:eu-repo/semantics/publishedVersion
dc.type
info:eu-repo/semantics/bookPart
dc.type
info:ar-repo/semantics/parte de libro
dc.date.updated
2022-01-27T18:11:55Z
dc.journal.pagination
289-320
dc.journal.pais
Suiza
dc.description.fil
Fil: Chiesa, Juan José. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Duhart, José Manuel. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Casiraghi, Leandro Pablo. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Paladino, Natalia. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Bussi, Ivana Leda. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Golombek, Diego Andrés. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/chapter/10.1007/978-3-319-08945-4_15
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1007/978-3-319-08945-4_15
dc.conicet.paginas
380
dc.source.titulo
Mechanisms of Circadian Systems in Animals and Their Clinical Relevance
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