Artículo
In vitro activity of combinations of zinc chelators with amphotericin B and posaconazole against six Mucorales species
Leonardelli, Florencia
; Macedo, Daiana
; Dudiuk, Catiana Beatriz
; Theill, Laura; Cabeza, Matías Sebastián
; Gamarra, Soledad; Garcia, Guillermo Manuel
Fecha de publicación:
05/2019
Editorial:
American Society for Microbiology
Revista:
Antimicrobial Agents and Chemotherapy
ISSN:
0066-4804
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Mucormycosis is an emerging disease with high mortality rates. Few antifungal drugs are active against Mucorales. Considering the low efficacy of monotherapy, combination-therapy strategies have been described. It is known that fungi are susceptible to zinc deprivation, so we tested the in vitro effect of the zinc chelators clioquinol, phenanthroline, and N,N,N=,N=-tetrakis(2-pyridylmethyl)ethane-1,2-diamine combined with amphotericin B or posaconazole against 25 strains of Mucorales. Clioquinol-posaconazole was the most active combination, although results were strain dependent.
Palabras clave:
ANTIFUNGAL SUSCEPTIBILITY TESTING
,
MUCORALES
,
POSACONAZOLE
,
ZINC CHELATORS
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Identificadores
Colecciones
Articulos(CCT - SANTA FE)
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - SANTA FE
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - SANTA FE
Citación
Leonardelli, Florencia; Macedo, Daiana; Dudiuk, Catiana Beatriz; Theill, Laura; Cabeza, Matías Sebastián; et al.; In vitro activity of combinations of zinc chelators with amphotericin B and posaconazole against six Mucorales species; American Society for Microbiology; Antimicrobial Agents and Chemotherapy; 63; 5; 5-2019; 1-13
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