Evento

In-vitro exposure to endocrine disruptors alters inflammatory markers in whole hypothalami and immortalized GnRH neurons

Riaño Gómez, Juan ManuelIcon ; Sorianello, Eleonora MarianaIcon ; Libertun, CarlosIcon ; Lux, Victoria Adela R.Icon ; Fernandez, Marina OlgaIcon
Tipo del evento: Virtual
Nombre del evento: ENDO 2021
Fecha del evento: 20/03/2021
Institución Organizadora: The Endocrine Society;
Título de la revista: Journal of the Endocrine Society
Editorial: Oxford University Press
ISSN: 2472-1972
Idioma: Inglés
Clasificación temática:

Resumen

Bisphenol A (BPA), a monomer of polycarbonate plastics, and Benzophenones (BPs), UV-filters, are endocrine disrupting chemicals (EDC). The hypothesis is that EDC exposure causes brain inflammation and predisposes animals to develop obesity and infertility. Previous results showed that the in-vitro exposure to BPA increases Glial Fibrillary Acidic Protein (GFAP) in hypothalami and IL-18 in mature GnRH neurons. Here, gene expression of cytokines (interleukins 6 and 1β, IL-6 and IL-1β) were evaluated in whole hypothalami of adult Balb/c mice and in immortalized GnRH neurons.
Palabras clave: GnRH NEURONS , INFLAMMATION , ENDOCRINE DISRUPTING , HYPOTALAMUS , ASTROCYTES , CYTOKINES
 
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/152272
URL: https://academic.oup.com/jes/article/5/Supplement_1/A490/6242175?searchresult=1
DOI: http://dx.doi.org/10.1210/jendso/bvab048.1002
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Eventos(IBYME)
Eventos de INST.DE BIOLOGIA Y MEDICINA EXPERIMENTAL (I)
Citación
In-vitro exposure to endocrine disruptors alters inflammatory markers in whole hypothalami and immortalized GnRH neurons; ENDO 2021; Washington; Estados Unidos; 2021; A490-A490
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