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dc.contributor.author
Sandrone, Silvana Silvia
dc.contributor.author
Repossi Marquez, Pablo Gaston
dc.contributor.author
Candolfi, Marianela
dc.contributor.author
Eynard, Aldo Renato
dc.date.available
2017-04-12T18:52:51Z
dc.date.issued
2014-10
dc.identifier.citation
Sandrone, Silvana Silvia; Repossi Marquez, Pablo Gaston; Candolfi, Marianela; Eynard, Aldo Renato; Polyunsaturated fatty acids and gliomas: a critical review of experimental, clinical, and epidemiologic data; Elsevier Inc; Nutrition; 30; 10; 10-2014; 1104-1109
dc.identifier.issn
0899-9007
dc.identifier.uri
http://hdl.handle.net/11336/15226
dc.description.abstract
Certain polyunsaturated fatty acids (PUFAs) called essential fatty acids (EFAs) cannot be biosynthesized by the body and hence, need to be obtained from diet. These PUFAs and their metabolites have multiple physiological functions that are altered in tumor cells due to a decreased expression of Δdelta-6-desaturase, which is an essential step in their metabolism. As a result, tumor cells would be protected from the toxic effect caused by free radicals, one product of EFA metabolism. EFAs have been proposed to have therapeutic potential in the treatment of glioblastoma. Gliomas are the most common primary tumors of the central nervous system in children and adults. High-grade gliomas remain a therapeutic challenge in neuro-oncology because there is no treatment that achieves a significant improvement in survival. Novel therapeutic strategies that use PUFAs for the treatment of gliomas have been assessed in cell cultures, rodent glioma models, and humans, with encouraging results. Here we review the latest progress made in the field.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Inc
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
Polyunsaturated Fatty Acids
dc.subject
Essential Fatty Acids
dc.subject
Glioma Treatment
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Central Nervous System Tumors
dc.subject.classification
Farmacología y Farmacia
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Polyunsaturated fatty acids and gliomas: a critical review of experimental, clinical, and epidemiologic data
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-04-07T14:27:51Z
dc.journal.volume
30
dc.journal.number
10
dc.journal.pagination
1104-1109
dc.journal.pais
Estados Unidos
dc.description.fil
Fil: Sandrone, Silvana Silvia. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Cordoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina. Provincia de Córdoba. Hospital Rawson. Servicio de Patología; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas; Argentina
dc.description.fil
Fil: Repossi Marquez, Pablo Gaston. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Cordoba. Instituto de Investigaciones En Ciencias de la Salud; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas; Argentina. Universidad Nacional de la Rioja; Argentina
dc.description.fil
Fil: Candolfi, Marianela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; Argentina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba; Argentina. Universidad de Buenos Aires; Argentina
dc.description.fil
Fil: Eynard, Aldo Renato. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Cordoba. Instituto de Investigaciones En Ciencias de la Salud; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas; Argentina
dc.journal.title
Nutrition
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0899900714000756
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.nut.2014.01.009
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