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dc.contributor.author
Carriquiriborde, Francisco Pablo
dc.contributor.author
Regidor, Victoria
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Aispuro, Pablo M.
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Gabrielli, Magali
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Bartel, Erika Belén
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Bottero, Daniela
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Hozbor, Daniela Flavia
dc.date.available
2022-02-17T20:09:24Z
dc.date.issued
2019-11
dc.identifier.citation
Carriquiriborde, Francisco Pablo; Regidor, Victoria; Aispuro, Pablo M.; Gabrielli, Magali; Bartel, Erika Belén; et al.; Rare detection of bordetella pertussis pertactin-deficient strains in Argentina; Centers Disease Control; Emerging Infectious Diseases; 25; 11; 11-2019; 2048-2054
dc.identifier.issn
1080-6059
dc.identifier.uri
http://hdl.handle.net/11336/152229
dc.description.abstract
Pertussis resurgence had been attributed to waning vaccine immunity and Bordetella pertussis adaptation to escape vaccine-induced immunity. Circulating bacteria differ genotypically from strains used in production of pertussis vaccine. Pertactin-deficient strains are highly prevalent in countries that use acellular vaccine (aP), suggesting strong aP-imposed selection of circulating bacteria. To corroborate this hypothesis, systematic studies on pertactin prevalence of infection in countries using whole-cell vaccine are needed. We provide pertussis epidemiologic data and molecular characterization of B. pertussis isolates from Buenos Aires, Argentina, during 2000-2017. This area used primary vaccination with whole-cell vaccine. Since 2002, pertussis case incidences increased at regular 4-year outbreaks; most cases were in infants <1 year of age. Of the B. pertussis isolates analyzed, 90.6% (317/350) contained the ptxP3-ptxA1-prn2-fim3-2 allelic profile. Immunoblotting and sequencing techniques detected only the 2 pertactin-deficient isolates. The low prevalence of pertactin-deficient strains in Argentina suggests that loss of pertactin gene expression might be driven by aP vaccine.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Centers Disease Control
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
ACELLULAR VACCINE
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ARGENTINA
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BACTERIA
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BORDETELLA PERTUSSIS
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PERTACTIN
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PERTACTIN-DEFICIENT STRAINS
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PERTUSSIS
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PRIMARY VACCINATION SERIES
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RESURGENCE
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VACCINATION
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VACCINES
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WHOLE-CELL VACCINE
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Epidemiología
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Ciencias de la Salud
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Rare detection of bordetella pertussis pertactin-deficient strains in Argentina
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-11-25T16:42:22Z
dc.identifier.eissn
1080-6040
dc.journal.volume
25
dc.journal.number
11
dc.journal.pagination
2048-2054
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Atlanta
dc.description.fil
Fil: Carriquiriborde, Francisco Pablo. Universidad Nacional de La Plata; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
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Fil: Regidor, Victoria. Universidad Nacional de La Plata; Argentina
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Fil: Aispuro, Pablo M.. Universidad Nacional de La Plata; Argentina
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Fil: Gabrielli, Magali. Universidad Nacional de La Plata; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
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Fil: Bartel, Erika Belén. Universidad Nacional de La Plata; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
dc.description.fil
Fil: Bottero, Daniela. Universidad Nacional de La Plata; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
dc.description.fil
Fil: Hozbor, Daniela Flavia. Universidad Nacional de La Plata; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
dc.journal.title
Emerging Infectious Diseases
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3201/eid2511.190329
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://wwwnc.cdc.gov/eid/article/25/11/19-0329_article
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