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dc.contributor.author
Goldstein Raij, Jorge
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dc.contributor.author
Ibarra, Cristina Adriana
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dc.contributor.author
Silberstein, Claudia Marcela
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dc.date.available
2022-02-17T17:15:19Z
dc.date.issued
2002-12
dc.identifier.citation
Goldstein Raij, Jorge; Ibarra, Cristina Adriana; Silberstein, Claudia Marcela; Adenylyl cyclase types I and VI but not II and V are selectively inhibited by nitric oxide; Associação Brasileira de Divulgação Científica; Brazilian Journal of Medical and Biological Research; 35; 2; 12-2002; 145-151
dc.identifier.issn
0100-879X
dc.identifier.uri
http://hdl.handle.net/11336/152212
dc.description.abstract
Adenylyl cyclase (AC) isoforms catalyze the synthesis of 3′,5′-cyclic AMP from ATP. These isoforms are critically involved in the regulation of gene transcription, metabolism, and ion channel activity among others. Nitric oxide (NO) is a gaseous product whose synthesis from L-arginine is catalyzed by the enzyme NO synthase. It has been well established that NO activates the enzyme guanylyl cyclase, but little has been reported on the effects of NO on other important second messengers, such as AC. In the present study, the effects of sodium nitroprusside (SNP), a nitric oxide-releasing compound, on COS-7 cells transfected with plasmids containing AC types I, II, V and VI were evaluated. Total inhibition (∼98.5%) of cAMP production was observed in COS-7 cells transfected with the AC I isoform and previously treated with SNP (10 mM) for 30 min, when stimulated with ionomycin. A high inhibition (∼76%) of cAMP production was also observed in COS-7 cells transfected with the AC VI isoform and previously treated with SNP (10 mM) for 30 min, when stimulated with forskolin. No effect on cAMP production was observed in cells transfected with AC isoforms II and V.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Associação Brasileira de Divulgação Científica
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/
dc.subject
ADENYLYL CYLASE
dc.subject
COS-7 CELLS
dc.subject
CYCLIC AMP
dc.subject
NITRIC OXIDE
dc.subject
SIGNAL TRANSDUCTION
dc.subject
SODIUM NITROPRUSSIDE
dc.subject.classification
Biofísica
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dc.subject.classification
Ciencias Biológicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Adenylyl cyclase types I and VI but not II and V are selectively inhibited by nitric oxide
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2021-12-03T20:49:54Z
dc.identifier.eissn
1414-431X
dc.journal.volume
35
dc.journal.number
2
dc.journal.pagination
145-151
dc.journal.pais
Brasil
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dc.journal.ciudad
San Pablo
dc.description.fil
Fil: Goldstein Raij, Jorge. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas. Laboratorio de Fisiopatogenia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
dc.description.fil
Fil: Ibarra, Cristina Adriana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas. Laboratorio de Fisiopatogenia; Argentina
dc.description.fil
Fil: Silberstein, Claudia Marcela. Universidad de Buenos Aires; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas. Laboratorio de Fisiopatogenia; Argentina
dc.journal.title
Brazilian Journal of Medical and Biological Research
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.scielo.br/j/bjmbr/a/DkM6kWr5mgTkc6wrYGycngH/?lang=en
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1590/S0100-879X2002000200002
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