Artículo
The extent of infectious SARS-CoV-2 shedding in an Argentinean cohort
Blanco, Sebastian; Aguilar, Juan Javier; Konigheim, Brenda Salome
; Diaz, Luis Adrian
; Spinsanti, Lorena Ivana; Beranek, Mauricio Daniel
; Collino, César; Diaz, Miguel; Barbás, María Gabriela; Gallego, Sandra Veronica
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Fecha de publicación:
09/2021
Editorial:
Oxford University Press
Revista:
Journal Of Public Health
ISSN:
1741-3842
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Background To analyze the infectious extent of severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) in different settings where prevention strategies are critical to limit infection spread, we evaluated SARS-COV-2 viability to guide public health policies regarding isolation criteria and infection control. Methods We attempted viral isolation in 82 nasopharyngeal swabs from 72 patients with confirmed SARS-COV-2 infection. Study population was divided into four groups: (i) Patients during the first week of symptoms; (ii) Patients with prolonged positive PCR; (iii) Healthcare workers from a hospital participating of an outbreak investigation, with SARS-COV-2 infection confirmed by reverse transcriptase polymerase chain reaction (RT-PCR) and (iv) Recipients of convalescent immune plasma (CIP). Vero Cl76 cell-line (ATCC CRL-587) was used in assays for virus isolation. Plasma samples of CIP recipients were also tested with plaque-reduction neutralization test. Results We obtained infectious SARS-COV-2 isolates from 15/84 nasopharyngeal swabs. The virus could not be isolated from upper respiratory tract samples collected 10-day after onset of symptoms (AOS) in patients with mild moderate disease. Conclusion The knowledge of the extent of SARS-CoV-2 infectivity AOS is relevant for effective prevention measures. This allows to discuss criteria for end isolation despite persistence of positive PCR and improve timing for hospital discharge with consequent availability of critical beds.
Palabras clave:
COVID-19
,
INFECTIVITY
,
ISOLATION
,
PUBLIC HEALTH
,
SARS-COV-2
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Colecciones
Articulos(CCT - CORDOBA)
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - CORDOBA
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - CORDOBA
Citación
Blanco, Sebastian; Aguilar, Juan Javier; Konigheim, Brenda Salome; Diaz, Luis Adrian; Spinsanti, Lorena Ivana; et al.; The extent of infectious SARS-CoV-2 shedding in an Argentinean cohort; Oxford University Press; Journal Of Public Health; 43; 3; 9-2021; E482-E486
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