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dc.contributor.author
Larcade, Ramon
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DeShea, Lise
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Lang, Gillian A.
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Caballero, Mauricio Tomás
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Ferretti, Adrian
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Beasley, William H.
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Tipple, Trent E.
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Vain, Néstor Eduardo
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Prudent, Luis
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Lang, Mark L.
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Polack, Fernando Pedro
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Ofman, Gaston
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dc.date.available
2022-02-16T12:19:39Z
dc.date.issued
2021-12
dc.identifier.citation
Larcade, Ramon; DeShea, Lise; Lang, Gillian A.; Caballero, Mauricio Tomás; Ferretti, Adrian; et al.; Maternal-fetal immunologic response to SARS-CoV-2 infection in a symptomatic vulnerable population: A prospective cohort; University of Chicago Press; Journal Of Infectious Diseases; 12-2021; 1-29
dc.identifier.issn
0022-1899
dc.identifier.uri
http://hdl.handle.net/11336/152100
dc.description.abstract
Background: COVID-19 disproportionally affects pregnant women and their newborn, yet little is known about the variables that modulate the maternal-fetal immune response to infection.Methods: We prospectively studied socioeconomic, biologic and clinical factors affecting humoral immunity in 87 unvaccinated pregnant women admitted to hospital in the Buenos Aires metropolitan area for symptoms consistent with COVID-19 disease.Results: The number of days between symptom onset and childbirth predicted maternal and newborn virus Spike protein Receptor Binding Domain (RBD)-specific IgG. These findings suggest newborns may benefit less when mothers deliver soon after COVID-19 infection. Similarly, a longer time between symptom onset and birth predicted higher in utero transfer of maternal IgG and its concentration in cord blood. Older gestational ages at birth were associated with lower maternal IgG: cord blood IgG ratios. Eighty seven percent of women with confirmed SARS-CoV-2 infection developed RBD-specific IgA responses in breast milk within 96 h of childbirth. IgA was not significantly associated with time from infection but correlated with maternal serum IgG and placental transfer.Conclusions: These results demonstrate the combined role of biologic, clinical and socioeconomic variables associated with maternal SARS-CoV-2 RBD-specific antibodies and supports early vaccination strategies for COVID-19 in socioeconomically vulnerable pregnant women.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
University of Chicago Press
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
SARS COV2
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COVID-19
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PREGNANCY
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ANTIBODIES
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Enfermedades Infecciosas
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Ciencias de la Salud
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CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Maternal-fetal immunologic response to SARS-CoV-2 infection in a symptomatic vulnerable population: A prospective cohort
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2022-02-15T14:20:01Z
dc.journal.pagination
1-29
dc.journal.pais
Estados Unidos
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dc.description.fil
Fil: Larcade, Ramon. No especifíca;
dc.description.fil
Fil: DeShea, Lise. Oklahoma State University; Estados Unidos
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Fil: Lang, Gillian A.. Oklahoma State University; Estados Unidos
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Fil: Caballero, Mauricio Tomás. Fundación para la Investigación en Infectología Infantil; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
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Fil: Ferretti, Adrian. Fundación para la Investigación en Infectología Infantil; Argentina
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Fil: Beasley, William H.. Oklahoma State University; Estados Unidos
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Fil: Tipple, Trent E.. Oklahoma State University; Estados Unidos
dc.description.fil
Fil: Vain, Néstor Eduardo. No especifíca;
dc.description.fil
Fil: Prudent, Luis. No especifíca;
dc.description.fil
Fil: Lang, Mark L.. Oklahoma State University; Estados Unidos
dc.description.fil
Fil: Polack, Fernando Pedro. Fundación para la Investigación en Infectología Infantil; Argentina
dc.description.fil
Fil: Ofman, Gaston. Fundación para la Investigación en Infectología Infantil; Argentina
dc.journal.title
Journal Of Infectious Diseases
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/jid/advance-article/doi/10.1093/infdis/jiab591/6448432
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1093/infdis/jiab591
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