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dc.contributor.author
Rodeles Antonelli, Luz María
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dc.contributor.author
Peverengo, Luz María
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dc.contributor.author
Benítez, Romina
dc.contributor.author
Benzaquen, Nadia
dc.contributor.author
Serravalle, Priscila
dc.contributor.author
Long, Ana Karina
dc.contributor.author
Ferreira, Virginia
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Benitez, Agostina Daiana
dc.contributor.author
Zunino, Luisina
dc.contributor.author
Lizarraga, Camila
dc.contributor.author
Vicco, Miguel Hernán
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dc.date.available
2022-02-16T12:18:53Z
dc.date.issued
2021-06
dc.identifier.citation
Rodeles Antonelli, Luz María; Peverengo, Luz María; Benítez, Romina; Benzaquen, Nadia; Serravalle, Priscila; et al.; Seroprevalence of anti-SARS-CoV-2 IgG in asymptomatic and pauci-symptomatic people over a 5 month survey in Argentina; Organización Panamericana de la Salud; Revista Panamericana de Salud Pública; 45; 1; 6-2021; 1-8
dc.identifier.issn
1020-4989
dc.identifier.uri
http://hdl.handle.net/11336/152097
dc.description.abstract
Objective. To evaluate the seroprevalence of COVID-19 infection in pauci-symptomatic and asymptomatic people, the associated epidemiological factors, and IgG antibody kinetic over a 5-month period to get a better knowledge of the disease transmissibility and the rate of susceptible persons that might be infected. Methods. Seroprevalence was evaluated by a cross-sectional study based on the general population of Santa Fe, Argentina (non-probabilistic sample) carried out between July and November 2020. A subgroup of 20 seropositive individuals was followed-up to analyze IgG persistence. For the IgG anti-SARS-CoV-2 antibodies detection, the COVID-AR IgG® ELISA kit was used. Results. 3 000 individuals were included conforming asymptomatic and pauci-symptomatic groups (n=1 500 each). From the total sample, only 8.83% (n=265) presented reactivity for IgG anti-SARS-CoV-2. A significant association was observed between positive anti-SARS-CoV-2 IgG and a history of contact with a confirmed case; the transmission rate within households was approximately 30%. In the pauci-symptomatic group, among the seropositive ones, anosmia and fever presented an OR of 16.8 (95% CI 9.5-29.8) and 2.7 (95% CI 1.6-4.6), respectively (p <0.001). In asymptomatic patients, IgG levels were lower compared to pauci-symptomatic patients, tending to decline after 4 months since the symptoms onset. Conclusion. We observed a low seroprevalence, suggestive of a large population susceptible to the infection. Anosmia and fever were independent significant predictors for seropositivity. Asymptomatic patients showed lower levels of antibodies during the 5-month follow-up. IgG antibodies tended to decrease over the end of this period regardless of symptoms.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Organización Panamericana de la Salud
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
ANOSMIA
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ARGENTINA
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ASYMPTOMATIC DISEASES
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EPIDEMIOLOGY
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SARS-COV-2
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SEROPREVALENCE
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COVID-19
dc.subject.classification
Medicina Critica y de Emergencia
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dc.subject.classification
Medicina Clínica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Seroprevalence of anti-SARS-CoV-2 IgG in asymptomatic and pauci-symptomatic people over a 5 month survey in Argentina
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2022-02-15T14:21:11Z
dc.journal.volume
45
dc.journal.number
1
dc.journal.pagination
1-8
dc.journal.pais
Argentina
dc.description.fil
Fil: Rodeles Antonelli, Luz María. Universidad Nacional del Litoral; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina
dc.description.fil
Fil: Peverengo, Luz María. Universidad Nacional del Litoral; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina
dc.description.fil
Fil: Benítez, Romina. Centro de Especialidades Médicas; Argentina
dc.description.fil
Fil: Benzaquen, Nadia. Servicio de Cardiología Sanatorio de Diagnóstico y Tratamiento; Argentina
dc.description.fil
Fil: Serravalle, Priscila. Centro de Especialidades Médicas; Argentina
dc.description.fil
Fil: Long, Ana Karina. Centro de Especialidades Médicas; Argentina
dc.description.fil
Fil: Ferreira, Virginia. Centro de Especialidades Médicas; Argentina
dc.description.fil
Fil: Benitez, Agostina Daiana. Centro de Especialidades Médicas; Argentina
dc.description.fil
Fil: Zunino, Luisina. Centro de Especialidades Médicas; Argentina
dc.description.fil
Fil: Lizarraga, Camila. Centro de Especialidades Médicas; Argentina
dc.description.fil
Fil: Vicco, Miguel Hernán. Universidad Nacional del Litoral; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina
dc.journal.title
Revista Panamericana de Salud Pública
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.26633/RPSP.2021.66
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