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dc.contributor.author
Stringa, Pablo
dc.contributor.author
Toledano, Victor
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Papa Gobbi, Rodrigo
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Arreola, Miguel
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Largo, Carlota
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Machuca, Mariana
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Aguirre, Luis A.
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Rumbo, Martín
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López Collazo, Eduardo
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Hernández Oliveros, Francisco
dc.date.available
2022-02-14T21:18:57Z
dc.date.issued
2020-05-01
dc.identifier.citation
Stringa, Pablo; Toledano, Victor; Papa Gobbi, Rodrigo; Arreola, Miguel; Largo, Carlota; et al.; Galactomannan as a potential modulator of intestinal ischemia–reperfusion injury; Academic Press Inc Elsevier Science; Journal Of Surgical Research; 249; 01-5-2020; 232-240
dc.identifier.issn
0022-4804
dc.identifier.uri
http://hdl.handle.net/11336/151984
dc.description.abstract
Background: Galactomannan (GAL), a polysaccharide present on the cell wall of several fungi, has shown an ability to modulate inflammatory responses through the dectin-1 receptor in human macrophages. However, studies evaluating the modulatory properties of this polysaccharide in in vivo inflammatory scenarios are scarce. We hypothesized that GAL pretreatment would modulate local and remote damage related to intestinal reperfusion after an ischemic insult. Materials and methods: Adult male Balb/c mice were subjected to intestinal ischemia–reperfusion injury by reversible occlusion of the superior mesenteric artery, consisting of 45 min of ischemia followed by 3 or 24 h of reperfusion. Intragastric GAL (70 mg/kg) was administered 12 h before ischemia, and saline solution was used in the control animals. Jejunum, lung, and blood samples were taken for the analysis of histology, gene expression, plasma cytokine levels, and nitrosative stress. Results: Intestinal and lung histologic alterations were attenuated by GAL pretreatment, showing significant differences compared with nontreated animals. Interleukin 1β, monocyte chemoattractant protein 1, and IL-6 messenger RNA expression were considerably downregulated in the small intestine of the GAL group. In addition, GAL treatment significantly prevented plasma interleukin 6 and monocyte chemoattractant protein 1 upregulation and diminished nitrate and nitrite levels after 3 h of intestinal reperfusion. Conclusions: GAL pretreatment constitutes a novel and promising therapy to reduce local and remote damage triggered by intestinal ischemia–reperfusion injury. Further in vivo and in vitro studies to understand GAL's modulatory effects are warranted.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Academic Press Inc Elsevier Science
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
DIGESTIVE SYSTEM SURGICAL PROCEDURES
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INTESTINE
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MESENTERIC ISCHEMIA
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REPERFUSION INJURY
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Inmunología
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Galactomannan as a potential modulator of intestinal ischemia–reperfusion injury
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-12-09T15:24:52Z
dc.identifier.eissn
1095-8673
dc.journal.volume
249
dc.journal.pagination
232-240
dc.journal.pais
Estados Unidos
dc.description.fil
Fil: Stringa, Pablo. Hospital Universitario la Paz; España
dc.description.fil
Fil: Toledano, Victor. Hospital Universitario la Paz; España
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Fil: Papa Gobbi, Rodrigo. Hospital Universitario la Paz; España
dc.description.fil
Fil: Arreola, Miguel. Hospital Universitario la Paz; España
dc.description.fil
Fil: Largo, Carlota. Hospital Universitario la Paz; España
dc.description.fil
Fil: Machuca, Mariana. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina
dc.description.fil
Fil: Aguirre, Luis A.. Hospital Universitario la Paz; España
dc.description.fil
Fil: Rumbo, Martín. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Estudios Inmunológicos y Fisiopatológicos. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Estudios Inmunológicos y Fisiopatológicos; Argentina
dc.description.fil
Fil: López Collazo, Eduardo. Hospital Universitario la Paz; España
dc.description.fil
Fil: Hernández Oliveros, Francisco. Hospital Universitario la Paz; España
dc.journal.title
Journal Of Surgical Research
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S0022480419307565
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.jss.2019.10.027
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