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dc.contributor.author
Fernandez, Ariel  
dc.date.available
2022-02-14T20:19:54Z  
dc.date.issued
2019-01  
dc.identifier.citation
Fernandez, Ariel; Drug-based cancer therapy to overcome immune resistance by steering tumor evolution; Informa Healthcare; Expert Opinion On Drug Discovery; 14; 1; 1-2019; 5-8  
dc.identifier.issn
1746-0441  
dc.identifier.uri
http://hdl.handle.net/11336/151968  
dc.description.abstract
We argue that therapy must lead rather than follow vis-à-vis cancer evolution. Clinical experience suggests that the evading phenotype resulting from treatment can never be fully anticipated or eliminated when a single source of selection pressure is applied during treatment. Thus, therapy must steer cancer evolution and LIC may well become the underlying paradigm to overcome resistance in a therapeutic context where immune surveillance is maintained.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Informa Healthcare  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
CANCER EVOLUTION  
dc.subject
CANCER RESISTANCE  
dc.subject
IMMUNE CHECKPOINT INHIBITOR  
dc.subject
IMMUNE EVASION  
dc.subject
PHOSPHOINOSITIDE-3 KINASE INHIBITOR  
dc.subject
TARGETED THERAPY  
dc.subject.classification
Tecnologías que involucran la manipulación de células, tejidos, órganos o todo el organismo  
dc.subject.classification
Biotecnología de la Salud  
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
Drug-based cancer therapy to overcome immune resistance by steering tumor evolution  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2020-12-18T19:33:53Z  
dc.journal.volume
14  
dc.journal.number
1  
dc.journal.pagination
5-8  
dc.journal.pais
Reino Unido  
dc.journal.ciudad
Londres  
dc.description.fil
Fil: Fernandez, Ariel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina  
dc.journal.title
Expert Opinion On Drug Discovery  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/full/10.1080/17460441.2019.1550066  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1080/17460441.2019.1550066  

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